Hypoxia, HIF1 and glucose metabolism in the solid tumour

By N. Denko. Nature Reviews. Cancer, 2008

1,650 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/084cab7ee20efc335d903465b85ca42f6f863d39

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Navdeep S. Chandel
2. Y. Zhao
3. Ming Tan
4. I. Harris
5. Marcos López
6. Jie Zheng
7. Sang Hun Lee
8. L. Gray

In Molecular Biology

1. Navdeep S. Chandel
2. R. Shaw
3. S. Weinberg
4. R. Hamanaka
5. D. Shackelford
6. Y. Zhao
7. Ming Tan
8. I. Harris

Citations in the corpus

• Metabolic Modulation of Glioblastoma with Dichloroacetate (2010, background): “Although we studied mROS (mitochondrial superoxide), controversy exists whether HIF-1a activation in cancer is associated with an overall increase or decrease in ROS [reviewed in (28)].”
• The LKB1-AMPK pathway: metabolism and growth control in tumor suppression (2009, background): “Well-established HIF1 transcriptional targets that contain hypoxia-responsive elements in their promoters include angiogenic factors, such as vascular endothelial growth factor A ( VEGFA ) and angiopoetin 2 ( ANG2 ), several glycolytic enzymes and multiple members of the glucose transporter (GLUT) f”
• Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “…of HIF induces a number of metabolic Disease Models & Mechanisms 1359 The role of lipid synthesis in cancer REVIEW D ise as e M od el s & M ec ha ni sm s D M M alterations, most notably the induction of glycolysis and the inhibition of mitochondrial oxidative phosphorylation (Denko, 2008).”
• Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice (2016, background): “Because HIF-1 could induce high level of GLUT-1 under hypoxia conditions (17), the aforementioned higher level of GLUT-1 (Fig.”
• Regulation of pyruvate metabolism and human disease (2013, background): “In regards to pyruvate metabolism, HIF1 regulates factors involved in glycolysis as well as PDK1, MCT4, and LDHA [150, 151].”
• Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity (2010, methodology): “de Coo, University Medical Center, Rotterdam, Netherlands) were previously described and were cultured in DMEM supplemented with 100 μg/ml uridine and 1 mM pyruvate (4).”
• The Lin28/let-7 axis regulates glucose metabolism (2011, background): “Reprogramming toward glyco- lytic metabolism can increase a cancer cell’s ability to generate biomass, a phenomenon termed the ‘‘Warburg Effect’’ (Denko, 2008; Engelman et al., 2006; Gao et al., 2009; Guertin and Sabatini, 2007; Laplante and Sabatini, 2009; Vander Heiden et al., 2009; Yun et al., 20”