Mammalian defensins in immunity: more than just microbicidal.

By De Yang, A. Biragyn, L. Kwak, J. Oppenheim. Trends in immunology, 2002

742 citations recorded by the source corpus.

Subfields: Immunology, Microbiology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/55b2fc2952894304ee4890f82763fc9e7e430a99

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Citations in the corpus

Cathelicidins, multifunctional peptides of the innate immunity (2004, background): “The subsequent finding that various defensins and some cathelicidin peptides can also interact with host cells and trigger a variety of activities unrelated to direct microbial killing [6–9] has changed the way we look at these molecules.”
Mammalian defensins in the antimicrobial immune response (2005, background): “These studies demonstrate a link between the rapid expression of antimicrobial defensins and the recruitment of adaptive immune cells capable of directing a long-lasting cellular and/or humoral response to a potential pathoge”
The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (2011, background): “Besides their antibacterial properties, these cationic peptides have been shown to act as antiviral agents (325).”
Multifunctional cationic host defence peptides and their clinical applications (2011, neutral): “1) [38, 115, 116, 120].”
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis (2011, background): “For example, HBD1 and HBD2 (also known as DEFB4A) have chemoattractant activity for cells expressing CC-chemokine receptor 6 (CCR6), including dendritic cell”
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, background): “10 Cite this article as Cold Spring Harb Perspect Med 2013;3:a010306 w w w .p er sp ec ti ve si n m ed ic in e. o rg proposed as attractive candidates for the development of novel types of antibiotics (Yang et al. 2002).”
Peptide Antimicrobial Agents (2006, background): “of various immune cells at inflammatory sites (58, 266),”
Adhesion mechanisms regulating the migration of monocytes (2004, background): “However, the role of CXCL14 or other chemoattractants, such as DEFENSINS , has not been examined in the context of non-inflammatory recruitment of monocytes to tissue”
The co-evolution of host cationic antimicrobial peptides and microbial resistance (2006, background): “Many CAMPs have additional chemokine-like and immunomodulatory activities that orchestrate infection processes and could lead to the appropriate activation of adaptive immune response”
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection (2006, background): “In addition to antimicrobial activity, antimicrobial peptides were suggested to be multifunctional modulators of different immune reaction”