Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era
By Maria Kostakioti, M. Hadjifrangiskou, S. Hultgren. Cold Spring Harbor Perspectives in Medicine, 2013
944 citations recorded by the source corpus.
Biofilm formation constitutes an alternative lifestyle in which microorganisms adopt a multicellular behavior that facilitates and/or prolongs survival in diverse environmental niches. Biofilms form on biotic and abiotic surfaces both in the environment and in the healthcare setting. In hospital wards, the formation of biofilms on vents and medical equipment enables pathogens to persist as reservoirs that can readily spread to patients. Inside the host, biofilms allow pathogens to subvert innate immune defenses and are thus associated with long-term persistence. Here we provide a general review of the steps leading to biofilm formation on surfaces and with in eukaryotic cells, highlighting several medically important pathogens, and discuss recent advances on novel strategies aimed at biofilm prevention and/or dissolution.
Subfields: Ecology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c58475d00f03aee259e6b4a7765fbe196937fe75
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Citations in the corpus
- Silver Nanoparticles as Potential Antibacterial Agents (2015, background): “The mature biofilm is a real microbial community that exchanges and shares products in a dynamic manner [78].”
- Bacterial Extracellular Polysaccharides in Biofilm Formation and Function (2015, background): “Bacteria can elaborate multiple PSs, which are important in different strains and varying environmental conditions, including surface substrate, nutrition, and flow rate (7).”
- Potential application spectrum of microbial proteases for clean and green industrial production (2017, background): “EPS also facilitate survival in the adverse conditions and environments (Kostakioti et al. 2013).”