Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
By A. Armulik, G. Genové, C. Betsholtz. Developmental Cell, 2011
2,486 citations recorded by the source corpus.
Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology.
Subfields: Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/7bcc7c0371071635f5d179315b8c20846e762544
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
- Berislav Zlokovic
- A. Prat
- Cornelis J. F. van Noorden
- J. Biernaskie
- V. Horsley
- I. Klaassen
- R. Daneman
- Reinier O. Schlingemann
In Oncology
- Behnam Noorani
- P. Noble
- T. Hagemann
- Danyang Li
- Berislav Zlokovic
- Minghua Wu
- Jiurong Liang
- M. Capasso
Citations in the corpus
- Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. (2013, background): “The role of pericytes in development and (patho)physiology was recently reviewed in detail (Armulik et al., 2011).”
- Pattern recognition receptors in health and diseases (2021, background): “Human brain pericytes (HBPs) are an important component of the microvascular wall and contribute to the integrity of the blood–brain barrier (BBB).(411) It has been found that TLR4 and NOD1 are expressed in HBP, which also reveals that HBP has the ability to sense systemic infection or blood-borne P”
- Diabetes and Wound Angiogenesis (2017, background): “Markers used with some success include α-smooth muscle actin (α-SMA) neural/glial antigen-2 (NG-2), desmin, Regulator of G-protein signaling 5 (RGS5), and platelet-derived growth factor receptor (PDGFR)-β [15,19].”
- The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans (2021, background): “S1 to S16 Tables S1 to S9 References (40-95)”
- The tumor microenvironment at a glance (2012, background): “Perivascular stromal cells, known as pericytes, are an integral component of the tumor vasculature that provide structural support to blood vessels (Armulik et al., 2011).”
- Pericytes of the neurovascular unit: Key functions and signaling pathways (2016, background): “angiogenesis; (3) impaired phagocytosis causing CNS accumulation of neurotoxins; (4) CBF dysfunction and ischemic capillary obstruction; (5) increased”