Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.
By Michele De Palma, M. Venneri, R. Galli, Lucia Sergi Sergi, L. Politi, M. Sampaolesi, L. Naldini. Cancer Cell, 2005
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Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) are selectively recruited to spontaneous and orthotopic tumors, (3) promote angiogenesis in a paracrine manner, and (4) account for most of the proangiogenic activity of myeloid cells in tumors. Remarkably, TEM knockout completely prevented human glioma neovascularization in the mouse brain and induced substantial tumor regression. Besides TEMs and endothelial cells (ECs), Tie2 expression distinguished a rare population of tumor stroma-derived mesenchymal progenitors representing a primary source of tumor pericytes. Therefore, Tie2 expression characterizes three distinct cell types required for tumor neovascularization: ECs, proangiogenic cells of hematopoietic origin, and pericyte precursors of mesenchymal origin.
Subfields: Immunology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/9c9269ccfb85ddf3f90d5bf33ab6ecbf5a2b941a
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Citations in the corpus
- Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “onstration of TEM involvement in angiogenesis results from the evidence that the selective depletion of these cells in mice during early stages of tumor development leads to a significant reduction of tumor mass and vasculature [98].”
- Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. (2006, background): “The ablation of this specialized cell type remarkably reduced angiogenesis in the tumor and caused its regression (De Palma et al., 2005).”
- Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Tie-2 expression has also been demonstrated in subtypes of monocytes and macrophages (De Palma et al., 2005) and on certain pericytes (Cai et al., 2008b), potentially complicating the picture of cellular interactions.”
- Angiogenesis in life, disease and medicine (2005, background): “Tie2-expressing monocytes (TEMs), mast cells and platelets also release pro-angiogenic factor”