Resveratrol stimulates AMP kinase activity in neurons

By B. Dasgupta, J. Milbrandt. Proceedings of the National Academy of Sciences of the United States of America, 2007

750 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/541b8ceda877fa31e3c57b067e3c123d13e57563

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Citations in the corpus

Sirt1 and the Mitochondria (2016, background): “The work of Dasgupta and Milbrandt indicates that resveratrol could directly activate AMPK, at least in certain cell types, in a manner that is completely independent of Sirt1 activity (Dasgupta and Milbrandt, 2007).”
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “We and others have shown that resveratrol activates AMPK in cell culture and in vivo (Baur et al., 2006; Dasgupta and Milbrandt, 2007), and a study of AMPK knockout mice established that AMPK is required for many of the beneficial effects of resveratrol onmetabolic function (Umet al.”
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008, background): “Finally, the SIRT1 agonist resveratrol- shown to augment survival of mice on a high-calorie diet (Baur et al., 2006) and improve mitochondrial function (Lagouge et al., 2006) - induces phosphorylation and activation of AMPK (Baur et al., 2006) (Dasgupta and Milbrandt, 2007).”
Dietary Polyphenols and Their Biological Significance (2007, background): “Resveratrol had an impact on cognitive deficits by activating the phosphorylation of protein kinase C (PKC), secreting transthyretin to prevent Aβ aggregation in cultured rat hippocampal cells [77], and stimulating AMP kinase activity in Neuro2a cells and primary neurons [75].”
AMPK in Health and Disease. (2009, methodology): “The mammalian AMPK domain limits were established experimentally by partial proteolysis (395), and a stable rat 1(68-163) fragment was expressed and crystallized in the presence of -cyclodextrin (an 1-4 linked heptaglucan), as had previously been performed for other starch binding domain structural ”
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (2012, positive): “At low concentrations (%50 mM), resveratrol appears to activate AMPK without decreasing energy (Dasgupta and Milbrandt, 2007; Suchankova et al., 2009).”
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (2008, background): “Other proposed biochemical mechanisms of action of resveratrol that were not examined in this study may include stimulation of AMP kinase [35], and increased nitric oxide synthase activity [36–38].”
SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “Resveratrol has been shown to be an indirect activator of several proteins such as AMPK, an important enzyme for energy and glucose homeostasis (34, 70, 84, 146, 244, 296, 332).”
Transcriptional control of mitochondrial biogenesis and function. (2009, background): “Besides SIRT1, resveratrol may also activate AMPK (160).”
AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol (2009, background): “(12) showed that, at lower doses, resveratrol can activate AMPK through a Sirt1-independent manner.”
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “In addition, we evaluated the action of SRT1720 on AMPK, which has been demonstrated to be activated by resveratrol independently of SIRT1 (Baur et al., 2006; Dasgupta and Milbrandt, 2007).”