Interchromosomal associations between alternatively expressed loci

By Charalampos G Spilianakis, M. Lalioti, T. Town, G. Lee, R. Flavell. Nature, 2005

774 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/53cd718f3e6bb6945f7c6dd378bfcc10d6b82be4

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In Immunology

Citations in the corpus

Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells (2009, background): “Indeed, examples of interchromosomal interactions that regulate gene expression have been describe”
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X-chromosome (2013, background): “close spatial proximity (9, 17, 60), which could even reside on other chromosomes (61, 62).”
De novo identification of differentially methylated regions in the human genome (2015, background): “DMRs may occur throughout the genome, but have been identified particularly around the promoter regions of genes, within the body of genes, and at intergenic regulatory regions [9-13].”
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007, methodology): “Using this method, the interferon-γ gene, which is located on mouse chromosome 10, was shown to physically interact with parts of the T H 2 cytokine gene locus, which is located on chromosome 11, in naive T lymphocyte”
What is a gene, post-ENCODE? History and updated definition. (2007, background): “Enhancers, silencers Distant regulatory elements (Spilianakis et al. 2005) DNA sequences determining expression can be widely separated from one another in genome.”
Epigenetic control of T-helper-cell differentiation (2009, background): “, unpublished observations), including T H 1-specific chromatin looping that brings Ifng CNS+18–20 close to the Ifng promote”
Interchromosomal interactions and olfactory receptor choice. (2006, background): “Recent data in mice reveal the association of regulatory sites within the interferon-g locus on chromosome 10 with sites on chromosome 11 within a locus encoding the TH2 cytokine genes interleukin 4, 5, and 13 (Spilianakis et al., 2005).”
Nuclear organization of the genome and the potential for gene regulation (2007, background): “Interchromosomal interactions between the interferon gamma ( Ifng ) gene and the locus control region of the T-helper 2 (T H 2) cytokine locus are found by 3C and FISH in the nuclei of naive CD4 p T cell”
CTCF: Master Weaver of the Genome (2009, neutral): “…2007; Lomvardas et al., 2006), monoallelic gene expression (Apostolou and Thanos, 2008; Ling et al., 2006), X chromosome inactivation (Bacher et al., 2006; Xu et al., 2006), and develop- 1194 Cell 137, June 26, 2009 ©2009 Elsevier Inc. mentally regulated transcription (Spilianakis et al., 2005).”
Beyond the sequence: cellular organization of genome function. (2007, neutral): “This new paradigm was recently established by analysis of the Ifng and TH2 loci in naive T cells (Spilianakis et al., 2005).”
Intermingling of Chromosome Territories in Interphase Suggests Role in Translocations and Transcription-Dependent Associations (2006, background): “chromosomeshavebeen reported [17,18],whichare reminiscent”
Genetics of global gene expression (2006, background): “Even more complications arise from DNA elements that act directly to regulate distant genes through physical contact; interchromosomal interactions can result in ' cis -regulatory' DNA that acts on a different chromosom”
Transcriptional regulatory elements in the human genome. (2006, neutral): “The generality of this mechanism for LCR function is supported by the recent observation that similar long-range interactions also occur at the Th2 LCR (169).”