Transcriptional regulatory elements in the human genome.

By Glenn A. Maston, S. Evans, Michael R. Green. Annual review of genomics and human genetics (Print), 2006

1,033 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/50f0bc82134d073982f6e8e6a4d877fbd380c0f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

DEEP: a general computational framework for predicting enhancers (2014, background): “Although these regions have been extensively studied, their underlying transcriptional mechanism is not yet fully understood (3).”
DeepEnhancer: Predicting enhancers by convolutional neural networks (2016, background): “It is also known that enhancers usually work with promoters to regulate the expression of genes in a tissue specific way, making these short DNA sequences crucial in the understanding of complicated mechanisms of gene regulation and receiving more and more attentions in modern genomic studies [1]–[3”
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics (2019, methodology): “They have been used for probing the direct binding of a TF to the promoter, enhancer or silencer region of a target gene, thus leading to the initiation (56), increase (57) or repression of the transcription of the studied gene (58), respectively.”
Genomic Views of Distant-Acting Enhancers (2009, background): “The docking of RNA polymerase II to proximal promoter sequences and transcription initiation are fairly well characterized; by contrast, the mechanisms by which insulator and silencer elements buffer or repress gene regulation, respectively, are less well understoo”
Histone Modifications at Human Enhancers Reflect Global Cell Type-Specific Gene Expression (2009, background): “Next, we identified putative insulators in the ENCODE regions for these cell types based on CTCF binding, because mammalian insulators are generally understood to require CTCF to block promoter 2 enhancer interactions 3 .”
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project (2007, background): “A simple, commonplace view of transcriptional regulation involves five types of cis -acting regulatory sequences—promoters, enhancers, silencers, insulators and locus control regions 31 .”
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes (2013, neutral): “Much of the transcriptional control of mammalian development is due to the diverse activity of transcription factor-bound enhancers that control cell type-specific patterns of gene expression (Bulger and Groudine, 2011; Hawrylycz et al., 2012; Maston et al., 2006).”
Enhancer function: new insights into the regulation of tissue-specific gene expression (2011, neutral): “Transcription of eukaryotic genes is an exceedingly intricate process that requires the precise orchestration of a complex set of interactions among a myriad of proteins and DNA sequence”
Super-enhancers in the control of cell identity and disease. (2013, neutral): “…which play key roles in the control of cell type-specific gene expression programs (Bulger and Groudine, 2011; Calo and Wysocka, 2013; Carey, 1998; Lelli et al., 2012; Levine and Tjian, 2003; Maston et al., 2006; Ong and Corces, 2011; Panne, 2008; Spitz and Furlong, 2012; Xie and Ren, 2013).”
A User's Guide to the Encyclopedia of DNA Elements (ENCODE) (2011, background): “, promoters, enhancers, silencers, and insulators) that collectively modulate the magnitude, timing, and cell-specificity of gene expression [35].”
Ensembl regulation resources (2016, background): “Variants on the active sites of these interactions, or regulatory elements (8), have been shown to be driving forces of evolution (9, 10) and disease (11).”