The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

By E. Cretney, Annie Xin, Wei Shi, M. Minnich, F. Masson, Maria Miasari, G. Belz, Gordon K. Smyth, M. Busslinger, S. Nutt and 1 more. Nature Immunology, 2011

604 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/4d8ae3a153934cbae30f337595b86a30b266e24b

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In Immunology

1. F. Quintana
2. Arlene H. Sharpe
3. V. Kuchroo
4. D. Mathis
5. David A. Hafler
6. C. Benoist
7. Alexander Y. Rudensky
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Citations in the corpus

• Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses (2014, result): “Prdm1, a transcription factor that transactivates IL-10 expression (Cretney et al., 2011), was expressed in higher amounts in TIGIT+ Treg cells, consistent with increased production of IL-10 by these cells (Figures 2A, 2C, and S2A).”
• CD8+ T Cells: Foot Soldiers of the Immune System (2011, neutral): “IRF4 and Blimp-1 regulate IL-10 in a subset of Treg cells (Cretney et al., 2011).”
• The Microbiome in Infectious Disease and Inflammation (2012, neutral): “The transcription factors Blimp-1 and IRF4 are required for IL-10 production by mucosal Treg cells (238).”