Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

By H. Rosen, E. Goetzl. Nature reviews. Immunology, 2005

737 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/530bba81ba35699d5bbcbf2e5e7a97c6d6c84e22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Cyster
2. Susan R. Schwab

In Molecular Biology

1. Sarah Spiegel
2. Susan R. Schwab
3. S. Milstien
4. J. Cyster
5. Ulrich H. von Andrian
6. M. Wymann
7. R. Schneiter
8. K. Takabe

Citations in the corpus

• “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “…intravenous injection of S1P showed protective effects against lung injury caused by high-volume mechanical ventilation and intratracheal endotoxin instillation in an animal model (McVerry and Garcia, 2004) that was attributed to expression of S1P1 by endothelial cells (Rosen and Goetzl, 2005).”
• THE ALLIANCE OF SPHINGOSINE-1-PHOSPHATE AND ITS RECEPTORS IN IMMUNITY (2008, background): “S1P treatment increases the survival of B cells and T cell”
• Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “16.3) (Rosen and Goetzl, 2005).”
• Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. (2007, background): “S1P plays a key role in enabling lymphocyte egress from the thymus into the blood and from SLOs into the lymph (Cyster, 2005; Massberg and von Andrian, 2006; Rosen and Goetzl, 2005).”
• Immune cell migration in inflammation: present and future therapeutic targets (2005, neutral): “Pharmacological inhibition of this pathway with drugs such as FTY720 traps T cells in lymph nodes and primary organs, leading to peripheral T cell depletio”
• Lipid signalling in disease (2008, background): “; when phosphorylated by lipid kinases, however, sphingosine is converted into sphingosine-1-phosphate (S1P), which promotes cell growth and proliferation by a still poorly understood intracellular action as well as by extracellular signalling through a set of different G protein-coupled receptors ”
• Follicular shuttling of marginal zone B cells facilitates antigen transport (2008, background): “However, some studies have questioned the view that the requirement for S1P 1 indicates direct involvement of S1P in cell positioning and have instead suggested that the role of this ligand-receptor pair in lymphocyte function may be developmenta”
• Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “Exactly how small-molecule agonists of S1P 1 lead to the same inhibitory effect on egress as genetic deficiency in this receptor is a point of contentio”
• Astrocyte crosstalk in CNS inflammation (2020, background): “In addition, sphingolipids like sphingosine 1-phosphate (S1P) also drive NF-κB activation and play important roles in the regulation MS and EAE (Rosen and Goetzl, 2005; Rothhammer et al., 2017) (Fig.”