THE ALLIANCE OF SPHINGOSINE-1-PHOSPHATE AND ITS RECEPTORS IN IMMUNITY

By J. Rivera, R. Proia, A. Olivera. Nature reviews. Immunology, 2008

654 citations recorded by the source corpus.

Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1–S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2621f109f2b6beeb7d5c59a45c84b4f9c9243cf2

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In Molecular Biology

1. Michael G. Katze
2. Michael A. Wheeler
3. F. Scott
4. H. Rosen

Citations in the corpus

• Into the Eye of the Cytokine Storm (2012, background): “important role in innate immune responses (120)”
• Astrocyte crosstalk in CNS inflammation (2020, background): “S1P is a biologically active phospholipid generated from ceramide which controls proliferation of several cell types and leukocyte trafficking from lymphoid tissues into circulation (Rivera et al., 2008).”
• Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection (2011, background): “Chemical modulators of the sphingosine-1-phosphate (S1P) signaling system have provided insight into immune cell trafficking and immune responses (Rivera et al., 2008; Rosen et al., 2009).”