Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

By Yan Zheng, D. Danilenko, P. Valdez, I. Kasman, J. Eastham‐Anderson, Jianfeng Wu, Wenjun Ouyang. Nature, 2007

2,007 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/528f245b7518968a986045017fb2a447cf7d9779

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. D. Cua
2. J. Kolls
3. Wenjun Ouyang
4. Frank O. Nestle
5. Yan Zheng
6. V. Kuchroo
7. E. Bettelli
8. J. Krueger

In Immunology

1. A. Jetten
2. Dan R. Littman
3. C. Dong
4. D. Cua
5. V. Kuchroo
6. D. Artis
7. H. Spits
8. R. Flavell

In Oncology

1. D. Pardoll
2. W. Zou
3. R. Flavell
4. Hua Yu
5. A. Jetten
6. Charles G. Drake
7. Dan R. Littman
8. V. Kuchroo

Citations in the corpus

• CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4 (2022, background): “…findings that the combination of different cytokines (such as TGF β plus IL-6) induces Th17 cells or Th22 cells (Cua et al., 2003; Mangan et al., 2006; Zheng et al., 2007), and the combination of TNF α and IFN γ induces PANoptosis as characterized by inflammatory cell death (Karki et al., 2021).”
• Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “In a mouse model of dermal inflammation in which IL-23 is directly applied to the ear, IL-22 was essential in mediating inflammation [60].”
• IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. (2010, background): “β-defensins and cathelicidin) or by inducing epithelial proliferation, thereby increasing epithelial resistance to infection (28, 29, 41, 46, 47).”
• Th17 cells in human disease (2008, background): “Liang SC, et al. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment.”
• IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine (2012, neutral): “However, IL-22 can also promote pathological inflammatory responses in the skin 10 or intestine 11 in mouse models, and its concentration is increased in a variety of human diseases including psoriasis, rheumatoid arthritis, infections, and IBD 5 .”
• Psoriasis Pathogenesis and the Development of Novel, Targeted Immune Therapies (2017, neutral): “IL-17 also acts synergistically with TNF to potentiate IL-17–induced transcription of several proinflammatory genes (eg, TNF, IL-1b, IL-6, and IL-8),47-50 which activate mDCs and promote the differentiation of T17 cells in the skin and draining lymph nodes.32,51 Epidermal hyperplasia, a hallmark of ”