PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

By Adrienne Boire, L. Covic, A. Agarwal, S. Jacques, Sheida Sherifi, A. Kuliopulos. Cell, 2005

838 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/51fbfd5cb8b1195d272e5dd43ae406f5192b046f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Gillian Murphy
2. R. Khalil
3. Hideaki Nagase
4. Xi Wang
5. Zena Werb
6. E. Deryugina
7. V. Plaks
8. James P. Quigley

In Genetics

1. Gillian Murphy
2. Xi Wang
3. R. Khalil
4. Zena Werb
5. V. Plaks

In Hematology

1. Gillian Murphy
2. Hideaki Nagase
3. Zena Werb
4. R. Khalil
5. Xi Wang
6. V. Plaks
7. James P. Quigley
8. E. Deryugina

Citations in the corpus

• Matrix metalloproteinases and tumor metastasis (2006, background): “Expression of MMP-1 in stromal fibroblasts has been shown to specifically confer tumorigenicity and high invasion potential to breast carcinoma cells in a mammary fat pad rat xenograft model [134].”
• Fibroblast heterogeneity in the cancer wound (2014, background): “In addition, MMPs stimulate protease-activated receptors (PARs) on the surface of neoplastic cells, thereby promoting growth and invasion (Boire et al., 2005).”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “MMP-1 promotes growth and invasion of cells by binding to and cleavage of protease-activated receptor-1 (PAR-1), which reveals a tethered ligand that initiates signaling via a G-protein coupled receptor (GPCR) and stimulates cell migration (Boire et al., 2005).”
• Tumor microenvironment: The role of the tumor stroma in cancer (2007, background): “As a family of compounds, the MMPs act to hydrolyze the extracellular proteins of the surrounding tissue which include collagen, laminin, elastin, fibrinogen, fibronectin, and vitronectin [Sternlicht and Werb, 2001; Boire et al., 2005].”
• Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “cer cell migration and invasive behavior of the tumor (Boire et al., 2005).”
• Fibroblasts in cancer (2006, neutral): “In addition to secreting growth factors that directly affect cell motility, activated fibroblasts are a source of ECM-degrading proteases such as the MMP”
• Structure and function of matrix metalloproteinases and TIMPs. (2006, positive): “Keratinocyte migration and reepithelialization MMP-1 Type I collagen Osteoclast activation MMP-13 Type I collagen Neurite outgrowth MMP-2 Chondroitinsulphate proteoglycan Adipocyte differentiation, MMP-7, Fibronectin cell migration MMP-1,-2, and -3 Fibronectin cell migration MT1-MMP CD44 Mammary epi”
• New signals from the invasive front (2006, background): “Although thrombin is usually the main ligand for PARs, in a xenograft mouse model of breast cancer it is predominantly MMP1, secreted by fibroblasts, that binds and activates PAR1 in cancer cells, resulting in tumour-cell migration and invasio”