Fibroblast heterogeneity in the cancer wound

By D. Öhlund, Ela Elyada, D. Tuveson. Journal of Experimental Medicine, 2014

857 citations recorded by the source corpus.

Dr. Tuveson and colleagues provide a comprehensive review on the fundamental role of cancer-associated fibroblasts in shaping the tumor microenvironment and promoting tumor initiation and progression.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/94000336d35e24cb71c080f2c8af032cd9229492

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In Cell Biology

Rakesh K. Jain

In Molecular Biology

In Oncology

Citations in the corpus

Tumor-associated stromal cells as key contributors to the tumor microenvironment (2016, background): “Fibroblasts regulate the structure and function of healthy tissues via extracellular matrix remodeling and transient tissue repair during wound healing [17].”
FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling. (2016, background): “3 Introduction Cancer-associated fibroblasts (CAFs) are the most prominent stromal components, and play important roles in modulating the tumor microenvironment and influencing the behavior of tumor cells primarily by releasing proteolytic enzymes, growth factors and cytokines (1,2).”
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy (2016, background): “Overexpression of miR-27a/b in normal fibroblasts results in up-regulation of α-SMA and TGF-β (i.e., acquisition of a CAF phenotype), a phenotype that is CAF-specific, since transfection of miR-27a/b in esophageal cancer cells has no significant impact on chemosensitivity.”
ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, positive): “…various immune cell populations (Gr-1+ myeloid cells Cancer Cell 26, November 10, 2014 ª2014 Elsevier Inc. 611 and T helper 17 cells) and fibroblasts have been implicated in resistance to AA therapy (Chung et al., 2013; Hanahan andCoussens, 2012; Noy and Pollard, 2014; Öhlund et al., 2014).”
Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. (2019, background): “Among these stromal cells, cancer-associated fibroblasts (CAF) play a major role in facilitating tumor growth (3).”
In search of definitions: Cancer‐associated fibroblasts and their markers (2019, background): “Not specific for fibroblasts and expressed by numerous other cells, such as myeloid and T-cells.(17,29) Yes”