Fibroblasts in cancer

By Raghu Kalluri, M. Zeisberg. Nature Reviews. Cancer, 2006

4,705 citations recorded by the source corpus.

Tumours are known as wounds that do not heal — this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. Their production of growth factors, chemokines and extracellular matrix facilitates the angiogenic recruitment of endothelial cells and pericytes. Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/138bb942514e7e93a47b47c4f6cef8995ba3e19c

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Citations in the corpus

Hallmarks of cancer: the next generation. (2011, positive): “It is increasingly apparent that crosstalk between cancer cells and cells of the neoplastic stroma is involved in the acquired capability for invasive growth and metastasis (Egeblad et al., 2010; Qian and Pollard, 2010; Joyce and Pollard, 2009; Kalluri and Zeisberg, 2006).”
Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts (2010, methodology): “Levels of active TGF-β were measured using mink lung epithelial cells (MLECs) expressing a PAI-1 promoter-driven luciferase reporter construct (8), a kind gift from Daniel B.”
Fibroblasts in fibrosis: novel roles and mediators (2014, background): “Fibroblasts in and around tumors are persistently activated by tumor cells (Kalluri and Zeisberg, 2006).”
Fibroblast heterogeneity in the cancer wound (2014, background): “However, there is no consensus on their molecular definition (Kalluri and Zeisberg, 2006; Orimo and Weinberg, 2007; Pietras and Ostman, 2010; Xing et al., 2010).”
Hallmarks of cancer: interactions with the tumor stroma. (2010, neutral): “[2] R.”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “470 The origin of these cells in the stroma is not entirely clear.”
The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment (2020, background): “Fibroblasts regulate the structure and function of normal tissue by synthesizing ECM and accelerate tissue repair [64].”
Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. (2011, background): “Both the stromal and cancer cells produce proteases that continuously remodel the ECM (Kalluri & Zeisberg 2006), and a ﬁve-step process of ECM remodelling concomitant to the tumour cell migration has been proposed (Friedl & Wolf 2009).”