Structure and function of matrix metalloproteinases and TIMPs.

By Hideaki Nagase, R. Visse, Gillian Murphy. Cardiovascular Research, 2006

3,321 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/841bd3219dcf90fab8ba3781156cf14da95aac06

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Khalil
2. Gillian Murphy
3. Xi Wang
4. Hideaki Nagase
5. Zena Werb
6. M. Xue
7. C. Jackson
8. P. E. Van den Steen

In Molecular Biology

1. R. Khalil
2. Gillian Murphy
3. Xi Wang
4. M. Xue
5. C. Jackson
6. Hideaki Nagase
7. V. Plaks
8. Zena Werb

In Oncology

1. R. Khalil
2. Gillian Murphy
3. Xi Wang
4. Hideaki Nagase
5. M. Xue
6. C. Jackson
7. Zena Werb
8. V. Plaks

Citations in the corpus

• Extracellular matrix structure. (2016, background): “This domain is followed by a C-terminal hemopexin-like domain, which is responsible, except of MMP-7, for the substrate specificity and the non-proteolytic functions, such as interactions with the various MMPs and TIMPs [13, 278, 279] (Fig.”
• Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances (2018, background): “In particular, MMP-9, which plays vital roles in cancer cell invasion and tumor metastasis, is one of the most widely investigated MMPs.”
• Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. (2007, background): “The TIMPs are low-molecular-weight proteins ( 190 amino acids) that can complex noncovalently with high efficiency to active MMPs in a 1:1 molar ratio (40, 58, 73, 90, 130, 133, 293, 420, 507).”
• The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults (2016, background): “Degradation of collagen components of the extracellular matrix in keratoconus corneas favours changes in the expression of ECM enzymatic regulators, that is, gelatinase A andmatrixmetalloproteinase 2 (MMP-2), which digest the main structural elements of the ECM, namely, collagen IV, collagen V, fibr”
• Zinc in wound healing: Theoretical, experimental, and clinical aspects (2007, background): “Zinc oxide advanced the enzymatic breakdown of collagen fragments in vitro through MMPs, which, as discussed above, exhibit substrate specificity for most ECMmolecules.(86,116) Locally applied zinc oxide also enhanced the repair of ulcerated skin.”
• Molecular Mechanisms of Dermal Aging and Antiaging Approaches (2019, background): “Physiologically, MMPs are regulated by the specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which compose a family of four protease inhibitors: TIMP-1, TIMP-2, TIMP-3, and TIMP-4 [24].”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “Therefore, while MMP-2 is primarily a gelatinase, it can function much like the collagenase MMP-1, although in a weaker manner (Nagase et al., 2006).”