Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo.

By A. Wakkach, N. Fournier, V. Brun, J. Breittmayer, F. Cottrez, H. Groux. Immunity, 2003

905 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5036ae48e11f87bdebe701525e0b21c03fecb721

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells (2009, background): “IL-10 itself is known to inhibit upregulation of CD80, CD86 and major histocompatibility comple”
Regulatory T cells, tumour immunity and immunotherapy (2006, background): “However, immature and semi-mature DCs induced regulatory T cells in mic”
Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells (2004, background): “Recently, differentiation of a distinct dendritic cell subset in the presence of IL10 has been demonstrated that induces tolerance through the generation of Tr1 cells (38).”
Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses (2004, background): “These cells have also been shown to be potent inducers of regulatory T cells (24) and, therefore, may represent a unique subpopulation with the ability to suppress the protective immune response through various mechanisms.”
Inflammation and necrosis promote tumour growth (2004, background): “Although IFN-α is known to have immunostimulatory and anticancer properties, in the absence of appropriate stimulation, pDCs promote the development of regulatory CD8 + T cell”
Tolerogenic dendritic cells and the quest for transplant tolerance (2007, background): “and drive de novo differentiation of naturally occurring T Reg cells or T regulatory type 1 (T R 1) cells”
A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells (2007, background): “Conversely, IL-10-modified DCs maintain an immature phenotype and support IL-10 production by T cell”
Dendritic cell immunotherapy: mapping the way (2004, background): “Immature DCs have tolerogenic potential because they induce regulatory T cells and inhibit immune response”
Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen (2004, background): “Alternative explanations could be that immature lung pDCs are important for generating T reg cells after exposure of harmless antigen, as proposed in vitro by others (27, 29, 39, 43) and also shown indirectly ex vivo here (Fig.”
Dendritic-cell control of pathogen-driven T-cell polarization (2003, background): “In this respect, they resemble a CD45RB hi subset with a default ability to induce regulatory T cell”