Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

By P. Rodriguez, D. Quiceno, J. Zabaleta, Blair Ortiz, A. Zea, M. Piazuelo, A. Delgado, P. Correa, J. Brayer, E. Sotomayor and 3 more. Cancer Research, 2004

1,236 citations recorded by the source corpus.

Subfields: Biochemistry, Immunology

View Paper: https://www.semanticscholar.org/paper/5e1cc01b3860b7f79061a2712e2057c772f8e4b1

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Citations in the corpus

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes (2009, positive): “In contrast, human MDSC do not express CAT-2B and therefore do not uptake L-arginine.”
Arginase: an emerging key player in the mammalian immune system (2009, background): “Arginase was also shown to participate in the suppression of tumour-infiltrating lymphocytes in patients with prostate carcinoma (Bronte et al., 2005a), non small cell lung carcinoma (Rodriguez et al., 2004) and multiple myeloma (Serafini et al., 2006b).”
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives (2008, methodology): “Furthermore, the addition of arginase inhibitors N-Hydroxy-nor-L-Arg (Nor-NOHA) and N-Hydroxy-L-Arg (NOHA) or exogenous L-Arg reversed the CD3z loss (80).”
Metabolic Instruction of Immunity (2017, neutral): “TAMs, MDSCs, and tolerizing dendritic cells (DCs) can suppress TILs through expression of essential amino acid (EAA)-degrading enzymes such as Arg1 and indoleamine-2,3dioxygenase (IDO) (Figure 1) (Lee et al., 2002; Munn et al., 2002; Rodriguez, 2004; Uyttenhove et al., 2003).”
Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN (2009, background): “In fact, the levels of arginase message in control TANs were equal to or even higher than those in control TAMs.”
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma (2005, background): “Using the 3LL murine lung carcinoma, we recently demonstrated that L -arginine ( L -Arg) depletion in the microenvironment by arginase I–producing MSCs inhibited T cell receptor CD3 expression and blocked T cell functions (5).”
Coordinated regulation of myeloid cells by tumours (2012, background): “, and mouse macrophages produce ARG1, which deprives T cells of the L -arginine that is necessary for their growt”