Dendritic cell immunotherapy: mapping the way

By C. Figdor, I. D. de Vries, W. Lesterhuis, C. Melief. Nature Medicine, 2004

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Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy (2005, background): “Tumor antigen–loaded dendritic cell vaccines have been introduced in the clinic and have proven feasible and nontoxic, and both immunological and clinical responses have been observe”
Dendritic cells as therapeutic vaccines against cancer (2005, background): “Therefore, we consider that the proposal for standardization of DC-based vaccination protocols for the treatment of cance”
Simultaneous Activation of Viral Antigen-specific Memory CD4+ and CD8+ T-cells Using mRNA-electroporated CD40-activated Autologous B-cells (2006, background): “Cellular immunotherapy using antigen-loaded antigenpresenting cells (APCs) such as dendritic cells (DCs) has recently been the subject of several clinical trials, because it is now generally accepted that exploiting the immune regulatory capacities of these APCs holds great promise for the treatment”
Dendritic-cell trafficking to lymph nodes through lymphatic vessels (2005, background): “In several clinical settings, it would be appealing to take advantage of the knowledge that we have gained about the migratory properties of DCs to design strategies for their delivery to lymph nodes to effect immunomodulation: for example, for induction of an antitumour immune respons”