The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

By Jayanta Debnath, Kenna R. Mills, Nicole L Collins, M. Reginato, S. Muthuswamy, J. Brugge. Cell, 2002

825 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4fb9d3bffbbfa460f125e2e07a874f7053460a1f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. (2007, background): “Cells undergoing autophagic cell death have been observed to display signs of apoptosis [33, 34].”
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition (2005, methodology): “IGF-IR structures exhibited significant Ki67 staining on A ugust 17, 2017 jcb.rupress.org D ow nloaded from JCB • VOLUME 171 • NUMBER 6 • 20051026 at day 16, unlike parental MCF-10A cultures, which have arrested proliferation by this time period (Debnath et al., 2002).”
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways (2004, background): “This specific sensitivity of the luminal cells recalls the selective regulation of luminal apoptosis seen in three-dimensional models of immortalized mammary epithelial cell”
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “, 2005) and apoptotic signals that trigger lumen formation (Debnath et al., 2002).”
Death by design: apoptosis, necrosis and autophagy. (2004, background): “In previous studies, these authors showed that MCF-10A cells expressing the anti-apoptotic protein Bcl-XL were capable of lumen formation although with delayed kinetics [28].”
Antioxidant and Oncogene Rescue of Metabolic Defects Caused by Loss of Matrix Attachment (2009, methodology): “This stabilization correlated with the maintenance of ERK1 and ERK2 (also known as MAPK3 and MAPK1, respectively) activation and an enhancement of PI(3)K–AKT signalling (Fig.”
An integrated computational/experimental model of tumor invasion. (2006, background): “proliferation and luminal filling produce a complicated structure characterized by multiple acinar structures (53).”
Recent advances in three‐dimensional multicellular spheroid culture for biomedical research (2008, neutral): “[34].”
NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2 (2007, background): “In contrast, MCF10A/p65 cells formed disorganized structures that are reminiscent of those formed by MCF10A cells overexpressing the ErbB2 oncogene (Debnath et al., 2002; Figure 4a).”
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. (2006, background): “…are not attached to BM undergo apoptosis (Boudreau et al 1995), and apoptosis of cells in the center of the structures leads to formation of hollow lumina (Blatchford et al 1999, Debnath et al 2002, Mills et al 2004), a process similar to canalization of the ducts in vivo (Humphreys et al 1996).”