Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.

By C. Nelson, Mina J. Bissell. Annual Review of Cell and Developmental Biology, 2006

1,159 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8b93175b62d4479daa71937dcedd27c656ca5b77

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Citations in the corpus

Microenvironmental regulation of metastasis (2009, background): “Maintaining organ homeostasis can prevent neoplastic transformation in normal tissues by ensuring stable tissue structure, mediated by tight junction proteins and cell adhesion molecules such as β1 integrins and epithelial (E)-cadheri”
2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, background): “The changed morphology of the cells can affect their function [16, 17], the organization of the structures inside the cell, secretion and cell signalling [18, 19].”
Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression (2011, background): “Everyone appreciates that DNA is central to all things, but, as we have argued before, “the sequence of our genes are like the keys on the piano; it is the context that makes the music&rdquo”
Modeling tissue morphogenesis and cancer in 3D. (2007, positive): “…many such studies have been performed on cells grown as monolayers, 3D models are likely to provide data with greater physiological relevance for mathematical models of growth, signaling, migration/invasion, and morphogenesis (Hicks et al., 2006; Nelson and Bissell, 2006; Zaman et al., 2006).”
Interactions between extracellular matrix and growth factors in wound healing (2009, background): “Here we focus on the relevance of these interactions to wound healing, although they are broadly applicable to the processes of tissue generation and even homeostasis.(1,10) Before considering specific types of ECM-growth factor interactions, we briefly review the composition of the ECM and its role”
Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “Our review will only focus on stem cells, and we would refer the reader to the rich literature regarding cell– ECM interactions and the signaling that it induces in mature cells for a broader treatment of the subject (see (Butcher et al., 2009; Geiger et al., 2001; Nelson and Bissell, 2006; Schwartz”
The Extracellular Matrix In Development and Morphogenesis: A Dynamic View (2009, background): “exist for specific matrix molecules (Nelson and Bissell, 2006) though other examples have yet to be uncovered.”
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? (2007, background): “Influence of the microenvironment The influence of the microenvironment in tumour development is now well establishe”