Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death.

By R. C. Scott, G. Juhász, T. P. Neufeld. Current Biology, 2007

898 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ab72365677753fec1b67ab9a40f2d2a9a6d6366c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Guido Kroemer
2. Beth Levine
3. D. Klionsky
4. Zhifen Yang
5. C. Jung
6. Eric H. Baehrecke
7. Jing Cao
8. Seung-Hyun Ro

In Epidemiology

1. Guido Kroemer
2. Beth Levine
3. D. Klionsky
4. Zhifen Yang
5. N. Mizushima
6. Eric H. Baehrecke
7. E. Eskelinen
8. P. Saftig

In Molecular Biology

1. D. Klionsky
2. Guido Kroemer
3. Beth Levine
4. Eric H. Baehrecke
5. Zhifen Yang
6. M. Maiuri
7. Adi Kimchi
8. D. Berry

Citations in the corpus

• Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, result): “Atg1 is a serine–threonine kinase that functions in the signaling pathway activating autophagy [42–44].”
• Autophagic cell death: the story of a misnomer (2008, background): “melanogaster larvae, transgenic expression of a highly active atg1 mutant induces large-scale autophagy and premature degradation of salivary glands, which, although accompanied by an increase in apoptosi”
• An Overview of the Molecular Mechanism of Autophagy (2009, background): “In Drosophila, Atg1 activity is modulated by TORC1 as in yeast, because the induction of autophagy that results from the overexpression of Atg1 is suppressed when the TORC1 signaling pathway is impaired (Scott et al. 2007).”
• ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. (2009, background): “Recent studies have shown that ULK or Atg1 kinase activity is important for the regulation of autophagy (Tekinay et al., 2006; Scott et al., 2007; Hara et al., 2008), which agrees with our model that mTOR regulates autophagy through phosphorylation of the ULK complexes and inhibition of the kinase a”
• mTOR regulation of autophagy (2010, background): “With this regard, it is noteworthy that Atg1/ULK negatively regulates TORC1 and growth in Drosophila and several types of human cells [50,66,97].”
• Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. (2007, positive): “We tested whether induction of autophagy was sufficient to induce cell death in salivary glands by expressing Atg1, which was previously shown to be sufficient to induce autophagy and ectopic cell death in fat ( Scott et al., 2007 ).”