Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

By N. Hosogai, A. Fukuhara, K. Oshima, Yugo Miyata, Sachiyo Tanaka, Katsumori Segawa, S. Furukawa, Y. Tochino, R. Komuro, M. Matsuda and 1 more. Diabetes, 2007

1,278 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4fa06b6ea54ffb09dade9068773f5874d5b50826

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Citations in the corpus

• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. (2008, background): “They elicit the inhibition of adiponectin gene transcription illustrated by decreased adiponectin promoter and PPAR- g activity, by reduced adiponectin mRNA (messenger ribonucleic acid) stability and finally by a decline in adiponectin expression as shown in obese mice.(53,55) Simultaneous induction”
• The role for endoplasmic reticulum stress in diabetes mellitus. (2008, background): “This was replicated in vitro in hypoxia-exposed adipocytes, and interference with CHOP expression partially reversed the decrease in adiponectin mRNA levels (275).”
• Type 2 diabetes as an inflammatory disease (2011, background): “Hypoxia and neovascularization are also seen in rodent models of obesity in which the fat mass is rapidly expanding; for example during high-fat feedin”
• Fat Treg cells: a liaison between the immune and metabolic systems (2009, background): “Whether the influx of macrophages or the efflux (or death) of T reg cells proves upstream, both processes must be downstream of an initiating event, as yet undefined, though suggestions have included local hypoxi”
• Hypoxia and adipose tissue function and dysfunction in obesity. (2013, methodology): “White adipose tissue is an important site of lactate production, the amount released increasing in obesity (38, 79, 224).”
• 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “The expansion in adipose tissue accompanying dietary obesity is associated with a poor angiogenic response that contributes to adipose tissue hypoxia (296).”
• Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “Consequently, obesity-associated adipose tissue hypoxia has been demonstrated by several groups in human adipose tissue (3, 13, 24) and in rodent adipose tissue (20, 37, 53).”
• Chronic Inflammation in Obesity and the Metabolic Syndrome (2010, background): “Furthermore, hypoxia by itself inactivates the adiponectin promoter [96].”
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, unknown): “Interestingly, the adipose tissue of obese mice may also be hypoxic, another condition that can induce ER stress (Hosogai et al., 2007).”