The role for endoplasmic reticulum stress in diabetes mellitus.

By Decio L. Eizirik, A. K. Cardozo, M. Cnop. Endocrine reviews, 2008

1,177 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/85ecc6809efc3b86a67d5bccc70b25da0eba8be0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Kaufman
2. E. Gilbert
3. Zhuo Fu
4. Dongmin Liu
5. Afshin Samali
6. A. Gorman
7. M. Cnop
8. F. Urano

In Genetics

1. E. Gilbert
2. Zhuo Fu
3. Dongmin Liu
4. M. Cnop
5. F. Ortis
6. R. Kaufman
7. Lihua Julie Zhu
8. Decio L. Eizirik

In Surgery

1. E. Gilbert
2. Zhuo Fu
3. Dongmin Liu
4. R. Kaufman
5. M. Cnop
6. F. Ortis
7. Afshin Samali
8. F. Urano

Citations in the corpus

• Initiation and execution of lipotoxic ER stress in pancreatic β-cells (2008, methodology): “…the transcription factors ATF3 and CHOP, Jun N-terminal kinase (JNK), the Akt inhibitor TRB3, caspases 4 and 12, and the mitochondrial apoptosis pathway; the latter process might be activated through the downregulation of Bcl-2, activation of Bax/Bak, Bim, p53, PUMA and NOXA (Eizirik et al., 2008).”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “This component will presumably contribute to ER stress, which plays a significant role in dysfunction of β-cells under cytokine attack [229].”
• The role of inflammation in insulitis and β-cell loss in type 1 diabetes (2009, background): “Exposure of β cells to inflammatory cytokines or to dsRNA induces ER stress, which leads to accumulation of misfolded proteins in the ER and triggers the unfolded-protein response”
• The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. (2008, background): “ROS also appears to adversely affect insulin production by the pancreas and may lead to -cell apoptosis ( 27 ), further exacerbatingglucose-insulinhomeostasis.Additionally,once peripheral glucose homeostasis is compromised by skeletal muscle insulin resistance, hyperglycemia can lead to a further mi”
• Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome (2012, background): “Recent evidence suggests that endoplasmic reticulum (ER) stress also plays a role in the loss of b cells during the progression of type 1 and type 2 diabetes and Wolfram syndrome, a genetic form of diabetes and neurodegeneration (Eizirik et al., 2008; Oslowski and Urano, 2011).”
• Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes (2012, positive): “ER stress and the unfolded protein response (UPR) are also implicated in β-cell dysfunction [302].”