Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue

By Nils Halberg, Tayeba Khan, M. Trujillo, Ingrid Wernstedt-Asterholm, A. Attie, Shariq I. Sherwani, Zhao V. Wang, Shira Landskroner-Eiger, Sean P. Dineen, U. Magalang and 2 more. Molecular and Cellular Biology, 2009

721 citations recorded by the source corpus.

Subfields: Cancer Research, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/3bb117eb23d88a302c07f3497fedf4404f35dc4a

How researchers see this paper

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In Epidemiology

1. P. Scherer
2. P. Seale
3. A. Okunade
4. B. Patterson
5. Alexander Sakers
6. Mirian Krystel De Siqueira
7. Claudio J. Villanueva
8. Jun Yoshino

In Physiology

1. P. Scherer
2. P. Seale
3. Alexander Sakers
4. Mirian Krystel De Siqueira
5. Claudio J. Villanueva
6. Yu A. An
7. Jun Yoshino
8. E. Ravussin

Citations in the corpus

• Transcriptional control of adipose lipid handling by IRF4 (2011, neutral): “Additionally, other problems have been associated with the Fabp4-Cre mouse, including poor recombination efficiency (Halberg et al., 2009).”
• Fibrosis and Adipose Tissue Dysfunction (2013, background): “Similar dysfunctional HIF1 signaling as seen in rodents seems to prevail in human AT (Halberg et al., 2009a; Jiang et al., 2011; Krishnan et al., 2012).”
• Adipose tissue plasticity in health and disease (2022, background): “Additionally, during obesity, hypoxia-induced signaling through HIF1a exerts potent profibrotic, rather than angiogenic, effects in adipose tissue, further driving adipose-tissue dysfunction (Halberg et al., 2009; Sun et al., 2013a).”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “In addition, it has been proposed that adipose tissue fibrosis in obese subjects caused by excess deposition of collagen, including type VI, leads to adipose tissue inflammation by triggering the infiltration of immune cells, such as macrophages, neutrophils, and lymphocytes (87, 182, 183).”
• Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. (2016, background): “, 2013), and production of ECM components (Halberg et al., 2009; Sun et al., 2013), can influence insulin sensitivity and whole-body glucose and”
• The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance (2011, background): “Considering that the development of obesity is also associated with hypoxi”
• Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments (2023, background): “of insufficient angiogenesis owing to fast and excessive adipose tissue expansion, over-activating the transcription factor hypoxiainducible factor 1a (HIF-1a) that triggers fibrosis, enhances local inflammation and lowers insulin sensitivity (34, 41).”
• Adipocyte Inflammation is Essential for Healthy Adipose Tissue Expansion and Remodeling (2014, background): “In contrast, enhanced fibrosis increases the rate of adipocyte death (Halberg et al., 2009).”
• The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017, positive): “Interestingly, unlike acute AT expansion, the hypoxia response of obese ob/ob mice fails to induce VEGF expression, and instead a decrease in vascular density is observed (4).”