Hypoxia and adipose tissue function and dysfunction in obesity.
By P. Trayhurn. Physiological Reviews, 2013
826 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/515407e49949b765515034de4eda9f2710b961e5
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cardiology and Cardiovascular Medicine
In Epidemiology
- Jerrold M. Olefsky
- Alan R. Saltiel
- Jamal Naderi
- M. Longo
- C. Miele
- G. A. Raciti
- F. Beguinot
- Federica Zatterale
In Physiology
- Jerrold M. Olefsky
- Jamal Naderi
- Alexander Sakers
- M. Longo
- C. Miele
- Mirian Krystel De Siqueira
- Alan R. Saltiel
- G. A. Raciti
Citations in the corpus
- Inflammatory mechanisms linking obesity and metabolic disease (2017, background): “Exposure of adipose tissue in culture to hypoxic conditions can induce upregulation of numerous inflammatory genes (19).”
- Adipose tissue plasticity in health and disease (2022, background): “Hypoxia is believed to develop due to (1) the presence of hypertrophic adipocytes (reaching 200+ m m in diameter), which exceed the diffusion limit of O 2 (typically 100–200 m m in tissues) and (2) defects in postprandial blood flow and vascular density (Trayhurn, 2013).”
- Obesity and adverse breast cancer risk and outcome: mechanistic insights and strategies for intervention (2017, background): “and hypoxia induces adipocyte gene expression changes, including those of inflammation-related adipokines.(91) CA CANCER J CLIN 2017;67:378–397”
- Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “When hypoxia occurs in the adipose tissue, the expression levels of angiogenic factors and inflammatory response-associated genes are upregulated (86, 88, 89).”
- Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “Current evidence reveals that hypoxia develops as AT expands because of a relative under perfusion of the enlarged AT or increased oxygen utilization (Gealekman et al., 2011; Sun et al., 2011; Trayhurn, 2013; Lee et al., 2014).”
- What We Talk About When We Talk About Fat (2014, neutral): “Despite efforts to recruit new blood vessels during adipose tissue expansion, however, hypoxia may develop, though some studies have shown normal or even elevated oxygen tension in fat pads of obese subjects (Trayhurn, 2013).”