Type 2 diabetes as an inflammatory disease

By M. Donath, S. Shoelson. Nature reviews. Immunology, 2011

3,597 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/1d084dc07f3e42940603b7b3af9f851716e5c59b

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Citations in the corpus

Inflammatory responses and inflammation-associated diseases in organs (2015, background): “Similarly, cytokine and chemokine release from adipose tissues into the circulation promotes further inflammation in other tissues [116].”
Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes (2012, background): “The prevalence of type 2 diabetes has increased worldwide, and it has become a global health burden because of its drastic cardiovascular complications (1,2).”
Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). (2011, background): “As reviewed elsewhere, IL-1β–induced inflammation in islets of patients with type 2 diabetes also appears mediated through the NLRP3 inflammasome.(64)”
A ceramide-centric view of insulin resistance. (2012, background): “TLRs signal through IkKb and NFkB, and the Shoelson group has identified this pathway as an important contributor to impaired glucose tolerance (Cai et al., 2005; Donath and Shoelson, 2011; Kim et al., 2001; Yuan et al., 2001).”
The Sleep-Immune Crosstalk in Health and Disease (2019, background): “, HIV, RA), numerous other diseases emerged in the last decades for which mild systemic elevations of inflammatory markers are characteristic, including cardiovascular (481) and metabolic diseases (153), certain forms of chronic pain (23), certain cancers (165), and neurodegenerative diseases (9).”
Inflammation: The Common Pathway of Stress-Related Diseases (2017, background): “Therefore, adipose tissue macrophages produce a significant proportion of the inflammatory factors that are upregulated by obesity (Donath and Shoelson, 2011).”
Beta Cell Dysfunction and Insulin Resistance (2013, background): “Islet inflammation (insulitis) in type 2 diabetes is attributed to nutrient overload leading to metabolic exhaustion in beta cells (Donath and Shoelson, 2011).”
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. (2013, background): “…(T2D) is a leading cause of morbidity and mortality worldwide, and increasing evidence suggests chronic Immunity 38, 1154–1163, June 27, 2013 ª2013 Elsevier Inc. 1157 inflammation as an important pathogenetic factor in the development of insulin resistance and T2D (Donath and Shoelson, 2011).”
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “and chemokines [3].”