Brown adipose tissue: function and physiological significance.

By Barbara Cannon, J. Nedergaard. Physiological Reviews, 2004

1,367 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/4f3b034098fa0e8e0640ccc6c83d2b8f909b73d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. C. R. Kahn
2. Jun Wu
3. E. Rosen
4. S. Gesta
5. P. Seale
6. B. Spiegelman
7. S. Kajimura
8. Y. Tseng

In Epidemiology

1. B. Spiegelman
2. S. Kajimura
3. E. Rosen
4. P. Seale
5. Y. Tseng
6. C. R. Kahn
7. S. Gesta
8. Jun Wu

In Physiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. E. Rosen
5. Jun Wu
6. Y. Tseng
7. C. R. Kahn
8. S. Gesta

Citations in the corpus

• Recruited brown adipose tissue as an antiobesity agent in humans. (2013, positive): “In small rodents, prolonged cold exposure induces BAT hyperplasia (1).”
• Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. (2014, background): “As NST, mediated by BAT (Cannon and Nedergaard, 2004) and muscle (Bal et al.”
• Brown adipose tissue activity controls triglyceride clearance (2011, background): “2297" language="eng" relation="no"> Brown adipose tissue (BAT) burns fatty acids for heat production to defend the body against col”
• UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. (2009, neutral): “, ‘‘diet-adaptation-recruited norepinephrine-induced thermogenesis’’ (Cannon and Nedergaard, 2004).”
• Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. (2013, positive): “In rodents, the increase in NST can be fully attributed to BAT (9, 10).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “This futile cycle of proton pump and leak reduces mitochondrial membrane potential, which in turn drives high levels of substrate oxidation and results in the generation of heat (Cannon and Nedergaard, 2004; Lowell and Spiegelman, 2000).”
• Developmental origin of fat: tracking obesity to its source. (2007, positive): “This occurs through expression of uncoupling protein-1 (UCP-1), a 32 kDa protein found in the inner mitochondrial membrane, that allows dissipation of the proton electro- chemical gradient generated by respiration in the form of heat (Cannon and Nedergaard, 2004).”