Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.

By Paul Lee, J. Linderman, Sheila Smith, R. Brychta, Juan Wang, Christopher R Idelson, Rachel M. Perron, Charlotte D. Werner, G. Phan, U. Kammula and 4 more. Cell Metabolism, 2014

774 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/9532f206ba794e911d77f43988023890ebbf3679

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. E. Rosen
5. Haiming Cao
6. G. Hotamışlıgil

In Physiology

1. P. Seale
2. S. Kajimura
3. B. Spiegelman
4. E. Rosen
5. L. Sidossis
6. R. Scarpulla
7. Christoph Handschin
8. G. Hotamışlıgil

In Rehabilitation

1. S. Kajimura
2. B. Spiegelman
3. P. Seale

Citations in the corpus

• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, neutral): “Upregulation of circulating irisin has also been reported in adult humans during cold exposure (61).”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “The newly identified adipokine irisin has been reported to link muscle-induced shivering thermogenesis to FGF21-induced brown (beige) adipose tissue-mediated nonshivering thermogenesis (59).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “Human studies using18F-FDG-PET/CT scans found that adult human BAT activity increases after chronic cold exposure even in subjects who do not possess appreciable amounts of BAT before cold exposure (Lee et al., 2014b; van der Lans et al., 2013; Yoneshiro et al., 2013).”