UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.

By Helena M. Feldmann, V. Golozoubova, B. Cannon, J. Nedergaard. Cell Metabolism, 2009

1,324 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/6e09f7b3e6dfb6f987bbbbc07563adf65d66524a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. B. Cannon
5. Kosaku Shinoda
6. J. Nedergaard
7. Jun Wu
8. E. Wagner

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Jun Wu
5. J. Nedergaard
6. B. Cannon
7. Kosaku Shinoda
8. H. Ohno

In Rehabilitation

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Kosaku Shinoda
5. J. Nedergaard
6. H. Ohno
7. B. Cannon
8. L. Sidossis

Citations in the corpus

• Nonshivering thermogenesis and its adequate measurement in metabolic studies (2011, background): “However, later studies performed in mice housed at their thermoneutral temperature showed a development of obesity even on a regular chow diet, and to a greater extent on a high-fat diet (Feldmann et al., 2009).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “These animals display an increase in metabolic efficiency and gain more weight than wild-type controls when housed under thermoneutral conditions (Feldmann et al., 2009).”
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “Indeed, loss of UCP1 causes cold-intolerance as well as obesity at thermoneutality in mice [1,2].”
• The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue (2009, background): “, at thermoneutrality), ablation of UCP1 is in itself sufficient to induce obesity, particularly when the mice are presented with a high-fat diet (16).”
• Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling (2014, background): “in BAT activity can profoundly affect adaptive thermogenesis and glucose homeostasis (7,8).”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “When the UCP1 knockout mice were raised under thermoneutral conditions, they gained more weight and fat than their control littermates (Feldmann et al. 2009).”