Brown adipose tissue activity controls triglyceride clearance

By A. Bartelt, Oliver T. Bruns, R. Reimer, H. Hohenberg, H. Ittrich, K. Peldschus, M. Kaul, U. Tromsdorf, H. Weller, C. Waurisch and 8 more. Nature Medicine, 2011

1,569 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/b389ba74839aefccced1b50096be25f42c6c7ba8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Jun Wu
2. P. Seale
3. B. Spiegelman
4. S. Kajimura
5. R. Kaufman

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Jun Wu
5. P. Cohen
6. Alexander Sakers
7. Mirian Krystel De Siqueira
8. Claudio J. Villanueva

In Rehabilitation

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. L. Sidossis

Citations in the corpus

• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “234 GENES & DEVELOPMENT 27:234–250 2013 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/13; www.genesdev.org chain (ETC) (Krauss et al. 2005; Bartelt et al. 2011; Fedorenko et al. 2012).”
• Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. (2013, neutral): “There has been revitalized interest in BAT after the discovery of functional BAT in human adults in 2009 (1, 2, 13), not in the least because BAT activation may be able to counteract obesity and type 2 diabetes (27, 29).”
• Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. (2013, neutral): “Discussion The advances in brown adipose cell biology during the last decade have increased our understanding of the cellular origin (27–29), function (8, 13, 29), and adult human tissue distribution (2, 3, 7, 9) of BAT.”
• Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans (2014, neutral): “adiposity, glucose homeostasis, and insulin sensitivity (9,10).”
• Adipose tissue plasticity in health and disease (2022, background): “In addition to suppressing weight gain by elevating energy expenditure, thermogenic adipocytes improve systemic metabolism and insulin action by clearing triglyceride-rich lipoproteins, acylcarnitines, glucose and other potentially toxic metabolites such as branched-chain amino acids (BCAAs), which ”
• Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. (2012, background): “Also, we did not assess BAT utilization of fatty acids from circulating lipoproteins, another potential source of BAT energy substrates (22).”
• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, neutral): “Moreover, BAT clears 75% and 50% of the total glucose and triglycerides from the circulation, respectively (104).”
• Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist (2015, background): “In addition to improving energy balance, rodent models have shown that chronic stimulation of BAT leads to improved glucose tolerance and the release of adipokines that beneficially regulate metabolism (Bartelt et al., 2011; Hondares et al., 2011).”
• What We Talk About When We Talk About Fat (2014, neutral): “The potential benefits of BAT activation extend beyond weight loss, as BAT consumes significant amounts of lipid and, to a lesser but still significant extent, glucose (Bartelt et al., 2011; Ouellet et al., 2012).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “In fact, BAT functions as a major ‘‘metabolic sink’’ not only for glucose but also for lipoproteins and fatty acids (Bartelt et al., 2011), and presumably for other metabolites.”