Brown and beige fat: Physiological roles beyond heat-generation

By S. Kajimura, B. Spiegelman, P. Seale. Cell Metabolism, 2015

885 citations recorded by the source corpus.

Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ. Increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that may not be entirely mediated by UCP1. We aim to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes.

Subfields: Biochemistry, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/936a9159fd6b3baaeb1938ac72ccfb1483d286a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. Koji Yamano
2. N. Matsuda
3. Miyuki Sato
4. Mashun Onishi
5. Koji Okamoto

In Rehabilitation

1. Koji Yamano
2. N. Matsuda
3. Miyuki Sato
4. Mashun Onishi
5. Koji Okamoto

Citations in the corpus

• Molecular mechanisms and physiological functions of mitophagy (2021, positive): “…of mitochondria serve as fat tissues to store energy, beige adipocytes contain a large quantity of mitochondria and act in thermogenesis by uncoupling mitochondrial proton gradient in response to various cues such as chronic cold exposure and exercise (Harms & Seale, 2013; Kajimura et al , 2015).”
• Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (2017, positive): “Non-shivering thermogenesis is mainly mediated by activating brown and/or beige adipocytes (Harms and Seale, 2013; Kajimura et al., 2015).”