Inflammatory mechanisms in obesity.

By Margaret F. Gregor, G. Hotamışlıgil. Annual Review of Immunology, 2011

3,541 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/4d47c37e2b2cdb45ddaca7bb53f6f1206f3856b8

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In Cardiology and Cardiovascular Medicine

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Citations in the corpus

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “In T2D, activation of the stress kinase c-Jun NH2terminal kinase (JNK) phosphorylates IRS-1 at serine residues (IRS-1pSer), blocking downstream insulin signaling and causing peripheral insulin resistance (28).”
Immune Dysfunction as a Cause and Consequence of Malnutrition (2016, background): “Clinical symptoms of obesity include high percentage adipose tissue, high circulating levels of triglycerides, high blood pressure which can lead to cardiovascular disease, and high blood glucose levels reflecting insulin resistance which can lead to type-2 diabetes [4,6,9,25].”
Role of the Microbiota in Immunity and inflammation (2014, background): “Type II diabetes (T2D) is an inflammatory condition in which increased adiposity and metabolic defects drive chronic production of inflammatory cytokines such as TNF-a and IL-1 (Gregor and Hotamisligil, 2011).”
Stress, Inflammation, and Defense of Homeostasis (2014, background): “These include aging-associated inflammation (Goto, 2008), including age-related macular degeneration (Parmeggiani et al., 2012), as well as inflammation caused by metabolic stress, including obesity (Gregor and Hotamisligil, 2011; Odegaard and Chawla, 2013).”
Inflammaging and 'Garb-aging'. (2017, background): “The inflammatory state sustained by over-nutrition and diets rich in high fat has been indicated as “metaflammation” (see Box 3)[30].”
Host remodeling of the gut microbiome and metabolic changes during pregnancy. (2012, background): “Reduced insulin sensitivity has been correlated with changes in immune status in pregnancy, including elevated levels of circulating cytokines (e.g., TNF-a and IL-6; Kirwan et al., 2002) that are thought to drive obesity-associated metabolic inﬂammation (Gregor and Hotamisligil, 2011).”
The Intestinal Microbiome in Early Life: Health and Disease (2014, background): “Obesity has an inflammatory component that can account for the development of metabolic disease, reflected by higher levels of circulating inflammatory proteins, increased adipokine secretion by tissues, and dysregulated activation of leukocytes across various tissue sites, including the liver and b”