Host remodeling of the gut microbiome and metabolic changes during pregnancy.

By Omry Koren, Julia Goodrich, Tyler C. Cullender, A. Spor, K. Laitinen, Helene Kling Bäckhed, Antonio Gonzalez, J. Werner, Largus T. Angenent, Rob Knight and 4 more. Cell, 2012

2,011 citations recorded by the source corpus.

Many of the immune and metabolic changes occurring during normal pregnancy also describe metabolic syndrome. Gut microbiota can cause symptoms of metabolic syndrome in nonpregnant hosts. Here, to explore their role in pregnancy, we characterized fecal bacteria of 91 pregnant women of varying prepregnancy BMIs and gestational diabetes status and their infants. Similarities between infant-mother microbiotas increased with children's age, and the infant microbiota was unaffected by mother's health status. Gut microbiota changed dramatically from first (T1) to third (T3) trimesters, with vast expansion of diversity between mothers, an overall increase in Proteobacteria and Actinobacteria, and reduced richness. T3 stool showed strongest signs of inflammation and energy loss; however, microbiome gene repertoires were constant between trimesters. When transferred to germ-free mice, T3 microbiota induced greater adiposity and insulin insensitivity compared to T1. Our findings indicate that host-microbial interactions that impact host metabolism can occur and may be beneficial in pregnancy.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0b8c6e0bd3412a4f5b7ebe8837c1c16908bc594f

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In Endocrinology, Diabetes and Metabolism

Rob Knight

In Molecular Biology

In Physiology

Citations in the corpus

The Central Nervous System and the Gut Microbiome (2016, background): “CELL 9279 The Maternal Gut and Vaginal Microbiome during Pregnancy and Its Effect on Offspring Behavior The maternal microbiome is distinct and dynamically changing during pregnancy compared to other periods in female life (DiGiulio et al., 2015; Koren et al., 2012; MacIntyre et al., 2015; Nuriel-Oh”
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Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “During the first to the third trimester of pregnancy, major changes such as an overall increase in Proteobacteria and Actinobacteria and reduced richness have been reported owing to the major physiological changes (Koren et al., 2012).”
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Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome (2018, background): “0001), confirming that a longer time window is required to fully appreciate the maturation process from infant to an adult-like state (Koren et al., 2012; Yatsunenko et al., 2012).”
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The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Regarding ‘‘obese bacteria,’’ as noted above, they are also associated with weight gain during the third trimester of pregnancy (Koren et al. 2012), so that caution should be used in considering obese bacteria as harmful microbes.”
MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data (2017, background): “Such comparisons have been increasingly used to reveal microbiome compositional differences in different developmental stages (18) or across different populations (32).”
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