Immune Dysfunction as a Cause and Consequence of Malnutrition
By Claire D. Bourke, J. Berkley, A. Prendergast. Trends in immunology, 2016
633 citations recorded by the source corpus.
Malnutrition, which encompasses under- and overnutrition, is responsible for an enormous morbidity and mortality burden globally. Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect. Defects emerge before birth via modifications in the immunoepigenome of malnourished parents, and these may contribute to intergenerational cycles of malnutrition. This review summarizes key recent studies from experimental animals, in vitro models, and human cohorts, and proposes that immune dysfunction is both a cause and a consequence of malnutrition. Focusing on childhood undernutrition, we highlight gaps in current understanding of immune dysfunction in malnutrition, with a view to therapeutically targeting immune pathways as a novel means to reduce morbidity and mortality.
Subfields: Nutrition and Dietetics, Physiology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/3e9f298f1e7a3bdc91aab2020a508d9189496686
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Citations in the corpus
- The Human Microbiome and Child Growth - First 1000 Days and Beyond. (2019, background): “These intestinal pathologies, referred to as environmental enteric dysfunction (EED), in addition to chronic pathogen exposure and inflammatory stimuli may impair innate and acquired immune responses, thereby increasing infectious morbidity and undernutrition [75].”