Stress, Inflammation, and Defense of Homeostasis
By R. Chovatiya, R. Medzhitov. Molecules and Cells, 2014
636 citations recorded by the source corpus.
Inflammation is traditionally considered a defense response induced by infection or injury. However, inflammation can also be induced by tissue stress and malfunction in the absence of infection or overt tissue damage. Here we discuss the relationship between homeostasis, stress responses and inflammation. Stress responses have cell autonomous and cell extrinsic components, the latter contributing to tissue level adaptation to stress conditions. Inflammation can be thought of as the extreme end of a spectrum that ranges from homeostasis to stress response to bona fide inflammatory response. Inflammation can be triggered by two types of stimuli: extreme deviations of homeostasis or challenges that cause a disruption of homeostasis. This perspective may help to explain qualitative differences and functional outcomes of diverse inflammatory responses.
Subfields: Behavioral Neuroscience, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/22b65923da2dbb2bc5c0a02bf07ed3ee002023dc
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Citations in the corpus
- Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, neutral): “Immune cells have evolved the remarkable ability to monitor and sense abnormalities in the body—including pathogenic insult or divergence from homeostasis—and in response, they initiate protective and restorative programs (Chovatiya and Medzhitov, 2014).”
- The Sleep-Immune Crosstalk in Health and Disease (2019, background): “The typical inflammatory response is triggered by a local infection or tissue injury, involving PAMPs and DAMPs, and is traditionally thought of as a protective reaction that defends and restores physiological functions (111, 296).”
- Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure (2016, neutral): “TNFa (pg/mL) 9 (7-12) 20 (14-27) 29 (17-41) <0.”
- Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “Oxygen and nutrient concentration, interstitial fluid volume, pH, osmolarity, cell number, and cellular composition are all examples of regulated variables of tissue homeostasis (Chovatiya and Medzhitov, 2014 ).”