The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

By Lindsey J. Macpherson, B. Geierstanger, Veena Viswanath, M. Bandell, S. R. Eid, S. Hwang, Ardem Patapoutian. Current Biology, 2005

609 citations recorded by the source corpus.

Subfields: Plant Science, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/3d5749bf67e3ff4f7d3eae76d76cbd3ce2e67bde

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Plant Science

1. Ardem Patapoutian

In Sensory Systems

1. D. Julius
2. Clifford J. Woolf
3. Ardem Patapoutian
4. D. Bautista
5. A. Basbaum
6. A. Dhaka
7. Veena Viswanath
8. S. Jordt

Citations in the corpus

• TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, positive): “Heterologously expressed TRPA1 channels can be activated by isothiocyanate or thiosulfinate compounds, whichconstitutethepungentingredients of mustard oil and garlic, respectively (Bandell et al., 2004; Bautista et al., 2005; Jordt et al., 2004; Macpherson et al., 2005 ).”
• TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, positive): “It is activated by allyl isothiocyanate (mustard oil) and by other pungent chemicals including allicin (from garlic), cinnamaldehyde (cinnamon), methysalicylate (wintergreen), eugenol (cloves), and gingerol (ginger) (Jordt et al., 2004; Bandell et al., 2004; Bautista et al., 2005; Macpherson et al.,”
• TRPM8 is required for cold sensation in mice. (2007, neutral): “pounds (Bandell et al., 2004; Jordt et al., 2004; Macpherson et al., 2005; Story et al., 2003).”
• TRP channels and pain. (2013, background): “TRPA1 is activated by isothiocyanates and thiosulfinates that constitute pungent agents from mustard (e.g., wasabi) and allium (e.g., garlic and shallot) plants, respectively (Bandell et al. 2004, Bautista et al. 2005, Jordt et al. 2004, Macpherson et al. 2005) (Figure 5a).”
• Trp ion channels and temperature sensation. (2006, background): “(Bandell et al. 2004, Bautista et al. 2005, Jordt et al. 2004, Macpherson et al. 2005).”
• TRP Channels (2012, neutral): “In addition, TRPA1 functions as a quite promiscuous chemosensor, as it can be activated by a broad variety of natural compounds such as allyl isothiocyanate [the pungent compound in mustard oil (MO) and wasabi], allicin (from garlic), cinnemaldehyde (from cinnamon), menthol (from mint), tetra-hydroc”