Brown and beige fat: development, function and therapeutic potential

By Matthew J. Harms, P. Seale. Nature Medicine, 2013

2,178 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/49e6f92f923e054a730c9d9d405a7c19d0740974

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. R. Locksley
2. S. Kajimura
3. B. Spiegelman
4. A. Chawla
5. J. Odegaard
6. P. Seale
7. Lata Mukundan
8. Yifu Qiu

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. R. Locksley
5. A. Chawla
6. J. Odegaard
7. Lata Mukundan
8. Yifu Qiu

In Rehabilitation

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Koji Yamano
5. N. Matsuda
6. Miyuki Sato
7. Mashun Onishi
8. Koji Okamoto

Citations in the corpus

• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “Over the past few years a number of studies have identified positive or negative regulators of brown and beige adipocyte development, as summarized by recent reviews (Harms and Seale, 2013; Kajimura and Saito, 2014; Wu et al., 2013).”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “org April 2016 | Volume 7 | Article 30 “beiging” remodeling of SAT to the BAT phenotype (referred to as “adipose tissue browning”) (40, 43).”
• Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells (2015, background): “The free energy released from this series of oxidation-reduction reactions is coupled toproduction of an electrochemical gradient that can be used to drive ATP synthesis, membrane transport, and thermogenesis (Harms and Seale, 2013; Mitchell, 1961; Schleyer et al., 1982).”
• Molecular mechanisms and physiological functions of mitophagy (2021, positive): “…of mitochondria serve as fat tissues to store energy, beige adipocytes contain a large quantity of mitochondria and act in thermogenesis by uncoupling mitochondrial proton gradient in response to various cues such as chronic cold exposure and exercise (Harms & Seale, 2013; Kajimura et al , 2015).”
• A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. (2014, background): “Brown adipocytes induced in WAT, also known as ‘‘beige’’ or ‘‘brite’’ cells (Harms and Seale, 2013), are derived from a precursor population distinct from both mature white and brown adipocytes (Wang et al.”
• Activated Type 2 Innate Lymphoid Cells regulate Beige Fat Biogenesis (2014, positive): “Consistent with the distinct developmental lineages of beige and brown adipocytes (Harms and Seale, 2013), exposure to IL-4 did not alter the expression of brown fatmarkers in APspurified from scWAT (Figure S5D).”
• Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (2017, positive): “Given that activation of beige cells can suppress obesity and metabolic disease (Harms and Seale, 2013), the effect of an EODF regimen on diet-induced obesity (DIO) mice was explored.”
• Adipose tissue plasticity in health and disease (2022, background): “Many studies have shown that mice with increased thermogenic fat activity are protected against weight gain and metabolic dysfunction (Harms and Seale, 2013).”