The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.

By Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen, Bing Wang, Jin Jiang. Developmental Cell, 2008

645 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/49bd74470c008810d28cbdf505d30f42ad7800c1

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Citations in the corpus

The Hippo pathway: regulators and regulations. (2013, background): “YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death (Vassilev et al. 2001; Goulev et al. 2008; Wu et al. 2008; Zhang et al. 2008; Zhao et al. 2008).”
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, positive): “In Drosophila, Scalloped (Sd) is a transcription factor and key partner of Yki that mediates the function of Yki in tissue growth (Goulev et al., 2008; Wu et al., 2008; Zhang et al., 2008; Zhao et al., 2008).”
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009, background): “These activities are mediated by a Tead protein, Scalloped (Goulev et al., 2008; Wu et al., 2008; Zhang et al., 2008b).”
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “…that disrupt the binding of TAZ or YAP to TEADs abolish their ability to promote proliferation and tumorigenic overgrowth phenotypes (Lamar et al., 2012; Zhang et al., 2009; Zhao et al., 2008), suggesting that control of TEAD activity is crucial for many of the TAZ/YAP functions described.”
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals (2010, background): “The Hpo-Sav complex phosphorylates and activates the Wts-Mats complex (Wu et al., 2003; Wei et al., 2007), which in turn phosphorylates and inactivates the on- D coprotein Yki (Huang et al., 2005) by excluding the latter from the nucleus (Dong et al., 2007; Oh and Irvine, 2008), where it normally…”
Hippo signaling: growth control and beyond (2011, background): “Roles of Scalloped and Yorkie in Drosophila In Drosophila imaginal discs, the TEAD family transcription factor Scalloped (Sd) primarily mediates the function of Yki, which itself does not bind to DNA (Goulev et al., 2008; Wu et al., 2008; Zhang et al., 2008b; Zhao et al., 2008a).”
The Hippo Signaling Pathway in Development and Disease (2019, background): “, 2008), they were also shown to bind to various Hippo target genes such as diap1 (Koontz et al., 2013; Wu et al., 2008; Zhang et al., 2008) and CTGF in mammals (Zhao et al.”
Hippo pathway effector Yap promotes cardiac regeneration (2013, background): “The majority of the actions of Yap and Taz have been ascribed to their association with TEAD transcription factors (43, 44), and a dominant negative TEAD mutant was shown to be sufficient to block the proliferative activity of Yap in cardiomyocytes (34).”
Mechanisms of Hippo pathway regulation (2016, positive): “Yki regulates gene transcription through interacting with the Scalloped (Sd) transcription factor (Goulev et al. 2008; Wu et al. 2008; Zhang et al. 2008).”
TEAD mediates YAP-dependent gene induction and growth control. (2008, background): “During the preparation of this manuscript, it was reported that Sd mediates Hippo signaling downstream from Yki (Goulev et al. 2008; Wu et al. 2008; Zhang et al. 2008).”
The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “TEADs have been repeatedly isolated as main YAP and TAZ interacting transcription factors in mass-spectrometry experiments (29, 209, 252), in line with results in Drosophila, in which the TEAD homolog Scalloped was identified as key (although not exclusive) partner for Yorkie transcriptional activit”