Hippo pathway effector Yap promotes cardiac regeneration

By Mei Xin, Yuri Kim, L. Sutherland, M. Murakami, X. Qi, John R. McAnally, E. Porrello, A. Mahmoud, W. Tan, J. Shelton and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2013

879 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/23f17810552e70e42affaf9d5ba4365a4b052e23

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. K. Guan
2. S. Piccolo
3. Fa-Xing Yu
4. Bin Zhao
5. G. Halder
6. M. Cordenonsi
7. Randy L. Johnson
8. H. Park

In Molecular Biology

1. K. Guan
2. Fa-Xing Yu
3. Bin Zhao
4. S. Piccolo
5. Randy L. Johnson
6. G. Halder
7. Duojia Pan
8. M. Cordenonsi

Citations in the corpus

• The Hippo signaling pathway in stem cell biology and cancer (2014, positive): “YAP-expressing cardiomyocytes behave similar to embryonic cells with regard to their regenerative potential [120].”
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, positive): “Importantly, evenheterozygousdeletionofYapcompletely blocks liver tumorigenesis induced byNf2 knockout in mice, indicating that YAP activation is the major mechanism mediating the tumorigenic potential of Nf2mutations (Zhang et al., 2010).”
• The Hippo Signaling Pathway in Development and Disease (2019, background): “Interestingly, deletion of Yap abolished the regenerative capacity of the early neonatal mouse heart, and conversely, cardiac-specific YAP overexpression prolonged the regenerative capacity beyond the neonatal period (von Gise et al., 2012; Xin et al., 2013).”
• The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “, after cardiomyocyte maturation) was associated with progressive dilated cardiomyopathy, with thinning of the ventricular walls eventually causing lethal heart failure (232).”
• Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer (2014, positive): “Our findings are in agreement with the known role of Yap1 in regulating normal cell proliferation through a Tead-mediated transcriptional program (Ota and Sasaki, 2008; Zhao et al., 2008; Schlegelmilch et al., 2011; Zhang et al., 2011; von Gise et al., 2012; Xin et al., 2013).”
• The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response (2014, neutral): “…cell cycle postnatally have been identified (Bersell et al., 2009; Chen et al., 2013; Eulalio et al., 2012; Mahmoud et al., 2013; Porrello et al., 2011a; Sdek et al., 2011; Xin et al., 2013), the upstream signal that causes permanent cell-cycle arrest of most cardiomyocytes remains unknown.”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “Deletion of upstream Hippo pathway effectors, such as conditional deletion of Sav1 or Lats2 (Heallen et al., 2011), or induced expression of nuclear-localized S112A-Yap (von Gise et al., 2012; Xin et al., 2013), drives aberrant cardiomyocyte proliferation.”
• The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment (2013, positive): “Notably, forced overexpression of an activated, S127A phospho-site mutant form of YAP in the adult mouse heart promoted heart regeneration after myocardial infarction 28 .”