Hippo signaling: growth control and beyond

By G. Halder, Randy L. Johnson. Development, 2011

1,073 citations recorded by the source corpus.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/5cbbcc920199cc692aec7283d0180cd42aa403b7

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In Cell Biology

1. K. Guan
2. S. Piccolo
3. M. Cordenonsi
4. Bin Zhao
5. S. Dupont
6. Cun-Yu Wang
7. Jindan Yu
8. Lloyd H. Wang

Citations in the corpus

• The Hippo signaling pathway in stem cell biology and cancer (2014, neutral): “Previous studies in Drosophila have implicated the Hippo pathway as a central mechanism that restricts tissue overgrowth during development and it derailed under pathological conditions contributes to tumorigenesis [91].”
• E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components (2011, background): “Merlin interacts with Hippo pathway components Expanded and Kibra, which interacts with the Hpo kinase in Drosophila (18).”
• Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. (2012, background): “Mst1/2 kinases (Drosophila Hippo homologs) complex with the scaffold protein Sav1 to phosphorylate and activate the Lats1/2 kinases, which complex with another scaffold protein, Mob1 (Halder and Johnson 2011).”
• The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “The function of LATS/warts remained rather poorly investigated until 2003, when other core components of the Hippo cascade were identified by similar screens (61, 64, 74, 80, 168).”
• Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment (2013, background): “As early as the 1930s, ovarian wedge resection (4) was used for PCOS treatment to induce follicle growth, followed by recent success based on ovarian “drilling” by diathermy or laser (5).”
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, neutral): “The mammalian orthologs of Hpo, Sav, Wts, Mats, and Yki are Mammalian sterile 20-like 1/2 (MST1/2, also called STK4/3), Salvador (SAV1), Large tumor suppressor homolog 1/2 (LATS1/2), MOB kinase activator 1A/B (MOB1a/b), and Yes-associated protein (YAP)/transcriptional co-activator with PDZ binding m”
• Hippo pathway regulation by cell morphology and stress fibers (2011, background): “The Hippo signaling pathway is an evolutionarily conserved tumorsuppressor signaling pathway that plays an important role in regulation of cell proliferation (see Halder and Johnson, 2011; Pan, 2007; Reddy and Irvine, 2008; Saucedo and Edgar, 2007).”