Mechanisms of Hippo pathway regulation

By Z. Meng, Toshiro Moroishi, K. Guan. Genes & Development, 2016

1,486 citations recorded by the source corpus.

In this review, Meng et al. focus on recent developments in our understanding of the molecular actions of the core Hippo kinase cascade and discuss key open questions in Hippo pathway regulation and function.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/991402bf369fa4dee82d9cf14d8efba334d6308f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Molecular Biology

Citations in the corpus

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model (2017, background): “In the Hippo-YAP signalling pathway, YAP (Yes-associated protein) is activated by de-phosphorylation and translocated into the nucleus to bind TEA domain family transcription factors and thus stimulate the expression of target genes involved in cell proliferation and migration [28-30].”
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “At the biochemical level, YAP is regulated by the Hippo signaling pathway, largely through its phosphorylation (Meng et al., 2016).”
The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways (2022, background): “The Hippo pathway effectors YAP and TAZ are paralogous transcription co-activators that cooperate with TEAD transcription factors to activate genes involved in proliferation and organ growth (Figure 5E) (48,49).”
YAP/TAZ at the roots of cancer (2016, background): “…in cultured cells in association to YAP/TAZ inhibition by several upstream signals, and these biochemical findings, including some from our own group (Cordenonsi et al., 2011), have been interpreted as Hippo/LATS serving as unique bottleneck/integrator for YAP/TAZ regulation (Meng et al., 2016).”
The Hippo signalling pathway and its implications in human health and diseases (2022, background): “114 Thus, inhibitors of Hippo core kinases can be readily developed.”