Recognition of pathogen-associated molecular patterns by TLR family.
By Shizuo Akira, H. Hemmi. Immunology Letters, 2003
1,198 citations recorded by the source corpus.
Subfields: Immunology, Microbiology
View Paper: https://www.semanticscholar.org/paper/4778439c9f891bc36486721596a570c1639c1c00
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Shizuo Akira
- Satoshi Uematsu
- Mihai G. Netea
- N. Gow
- Teunis B. Geijtenbeek
- Y. Kooyk
- B. Magnadóttir
- Gordon D. Brown
In Microbiology
- Satoshi Uematsu
- Teunis B. Geijtenbeek
- B. Magnadóttir
- Gordon D. Brown
- Y. Kooyk
- Mihai G. Netea
- Shizuo Akira
Citations in the corpus
- Brain–Gut–Microbe Communication in Health and Disease (2011, background): “TLRs are present on cells of the innate immune system and recognize characteristic molecules called pathogen associated molecular patterns (PAMPS; Akira and Hemmi, 2003).”
- Toll-like receptors and innate immunity (2006, background): “Furthermore, murine TLR7 recognizes guanosine analogs such as loxoribine, which has antiviral and antitumor activities [47].”
- Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells (2006, background): “TLRs are crucial components of the innate immune system that recognize signature microbial compound”
- An integrated model of the recognition of Candida albicans by the innate immune system (2008, background): “Upon recognition of microbial structures, TLRs activate either the NF-κB or MAPK pathway, which lead to the stimulation of pro-inflammatory cytokine productio”
- Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists (2007, neutral): “TLR1, 2, 4, 5, 6 and 10 are expressed on the cell surface and migrate to phagosomes after activation, whereas TLR3, 7, 8 and 9 are expressed in intracellular compartments in nearly all cell types, principally in the endosomes and the endoplasmic reticulum, with the ligand-binding domains sampling th”
- Immunological Control of Fish Diseases (2010, background): “Important PRRs are the toll-like receptors (TLRs), which has received some attention in fish research in recent years (Akira and Hemmi 2003; Heine and Lien 2003; Takeda and Akira 2004).”
- DC-SIGN: escape mechanism for pathogens (2003, background): “Each TLR recognizes specific pathogenic components, such as lipoprotein, lipopolysaccharide (LPS) or bacterial DN”
- Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. (2004, background): “Innate immunity is closely linked to adaptive, acquired immunity[19,21].”