Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
By Jongdae Lee, J. Mo, K. Katakura, I. Alkalay, Adam N. Rucker, Yu-Tseung Liu, Hyun-ku Lee, Carol Shen, G. Cojocaru, S. Shenouda and 4 more. Nature Cell Biology, 2006
641 citations recorded by the source corpus.
Subfields: Cancer Research, Immunology, Surgery
View Paper: https://www.semanticscholar.org/paper/ed7654d80b1617cd1cb622c5ea6d304ba717cdd4
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Citations in the corpus
- Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function (2010, background): “Analysis of polarized human IECs in vitro indicated that TLR5 is expressed only on the basolateral surface, where it can trigger the production of cytokines and chemokines, such as IL-8 and CC-chemokine ligand 20 (CCL20), in response to basolateral flagelli”
- Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists (2007, positive): “TLR1, 2, 4, 5, 6 and 10 are expressed on the cell surface and migrate to phagosomes after activation, whereas TLR3, 7, 8 and 9 are expressed in intracellular compartments in nearly all cell types, principally in the endosomes and the endoplasmic reticulum, with the ligand-binding domains sampling th”
- Mechanisms of Action of Probiotics. (2019, background): “TLR9 triggers IκBα degradation and NF-κB pathway activation, whereas apical TLR9 induces cytoplasmic accumulation of ubiquitinated IκB and inhibition of NF-κB activation (71, 142).”
- Gut microbiota in health and disease. (2010, background): “(159) have shown that while activation of basolaterally located TLR9 promotes NF B activation, signaling originating from the apical surfaces (i.”