Preparing the "soil": the premetastatic niche.

By R. Kaplan, Shahin Rafii, D. Lyden. Cancer Research, 2006

664 citations recorded by the source corpus.

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Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability (2008, background): “Recent studies have demonstrated a role for the expression of LOX both in the initiation and growth of metastases in a rodent model system, possibly associated with maintenance of the postulated metastatic niche derived from bone marrow-derived haematopoietic progenitor cell”
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective (2010, positive): “This suggestion led to the concept of a premetastatic niche, whereby a special, permissive microenvironment in the secondary site is developed (156).”
Models, mechanisms and clinical evidence for cancer dormancy (2007, background): “By contrast, tumour cells that can remodel and/or reproduce a niche or orthotopic microenvironment that is conducive for expansion might be able to resume growt”
Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. (2011, background): “In accordance with the “seed and soil” hypothesis for example cancer stem cells or metastatic cells function as “seeds” and a particular organ microenvironment or niche serves as the “soil” (1-3).”