Engineering tumors with 3D scaffolds
By C. Fischbach, Ruth R. Chen, Takuya Matsumoto, T. Schmelzle, J. Brugge, P. Polverini, David J. Mooney. Nature Methods, 2007
822 citations recorded by the source corpus.
Subfields: Infectious Diseases, Parasitology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/d3536f7644afcf9e0ee329db4c83f252cf2fd887
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Citations in the corpus
- 3D Cell Culture Systems: Advantages and Applications (2015, background): “This shows that Matrigel grown tumors lack certain microenvironmental factors that the engineered tumors are provided with (Fischbach et al., 2007).”
- 2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, background): “In addition, adherent cultures are usually monocultures and allow for the study of only one cell type [27], which results in a lack of tumour”
- Three-Dimensional Cell Culture Matrices: State of the Art (2008, background): “Engineered tumors within the scaffolds not only recovered tumor-like morphology better than 2D carcinoma cell cultures, but also recuperated tumor functions better, such as enhanced angiogenic capability and reduced sensitivity to chemotherapy.(173) The internal architecture of scaffolds will need t”
- Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation (2012, methodology): “Since then, several methods have been used to generate tumor spheroids: spontaneous aggregation [19,20], spinner flasks [21], rotary cell culture systems [3,22], poly-2-hydroxyethyl methacrylate (polyHema)-coated plates [23,24], hanging drops [25], liquid overlay on agar [26-28], low binding plates ”
- Spherical Cancer Models in Tumor Biology (2015, methodology): “These models are based on different approaches as illustrated by the multicellular tumor spheroid model (MCTS) [4], organotypic slices of cancer tissue [5], multilayered cell cultures [6], and scaffolds [7].”
- Organ-on-a-Chip Platforms for Studying Drug Delivery Systems (2014, background): “cultured OSCC-3 oral squamous carcinoma cells within porous poly(lactide-co-glycolide) (PLG) scaffolds to create an in vitro tumor model [47].”