MET signalling: principles and functions in development, organ regeneration and cancer

By Livio Trusolino, A. Bertotti, P. Comoglio. Nature reviews. Molecular cell biology, 2010

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Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer (2013, neutral): “Hepatocyte growth factor, the ligand for the MET receptor, is expressed mainly in cells of mesenchymal origin, although some tumors appear to express both HGF and MET (25).”
Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, neutral): “Besides their control on the cell cycle and cell survival, many growth factors, includingHGF, EGF, FGF, and TGFb, share signaling through ERK, JNK, Src, mTOR, and PI3K pathways toward Rac and Cdc42 activation and enhanced cytoskeletal dynamics (Massagué, 2008; Shapiro et al., 2011; Trusolino et al.,”
An overview of the c-MET signaling pathway (2011, methodology): “Although the downstream response to c-MET is common to many RTKs, the potency, endurance and specificity of c-MET-triggered pathways is secured by a network of upstream signaling coreceptors that physically associate with c-MET at the cell surface (Figure 3) [Trusolino et al. 2010].”