Membrane vesicles traffic signals and facilitate group activities in a prokaryote

By Lauren M. Mashburn, M. Whiteley. Nature, 2005

816 citations recorded by the source corpus.

Subfields: Genetics, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/47241c10011b0181c371d741720b11351e5ff300

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In Genetics

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4. Steve Diggle
5. M. Kuehn
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In Microbiology

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3. B. Cookson
4. Lindsay M. Aye
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In Molecular Biology

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Citations in the corpus

• Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “OMVs from the Gram-negative bacterium Pseudomonas aeruginosa contain signaling molecules, such as the hydrophobic 2-heptyl-3-hydroxy-4-quinolone, to coordinate group behavior of this bacterium (Mashburn and Whiteley, 2005; Winans, 2005).”
• A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms (2006, background): “Very recently it was shown that PQS is necessary for vesicle formation in P. aeruginosa (Mashburn and Whiteley, 2005), and evidence was presented that type IV pili and flagella are necessary for quorum sensing in P. aeruginosa (Hassett, 2005).”
• The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa (2006, methodology): “…of operons phzA1-G1 and phzA2-G2 This study PA14 DsoxR PA14 with a deletion in soxR This study PA14 DpqsH PA14 with an insertion in pqsH; GmR Mashburn and Whiteley (2005) PA14 phzM PA14 mutant with a GmR cassette inserted into PA4209 (phzM) Gift from P. Cornelis, Brussels, Belgium PAO1…”
• Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations. (2014, background): “aeruginosa are not readily diffusible across the membrane, either due to their lager size or hydrophobic nature [66,67].”
• Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “Quorum-sensing molecules or adhesins are also transported by OMVs and enable the bacteria to interact with eukaryotic cells (275).”
• The Social Lives of Microbes (2007, background): “…rather than public good; see Section 4.6) Membrane vesicles Common biofilm component (Schooling & Beveridge 2006), transport of cell-to-cell signals (Mashburn & Whiteley 2005) Rhamnolipids Antiprotozoan defense mechanism (Cosson et al. 2002), mediate detachment from biofilms (Boles et al. 2005)…”
• Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life (2012, background): “aeruginosa-produced quorum 144 sensing molecule pqs (54) alters membrane curvature (53), thereby inducing MV 145”
• Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation (2016, neutral): “Two clinically important bacteria that are well documented to produce OMVs during infections are Neisseria meningitidis and Pseudomonas aeruginosa (Mashburn and Whiteley, 2005; Namork and Brandtzaeg, 2002).”
• Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles (2010, background): “aeruginosa quorum-signaling molecule, PQS, is another type of insoluble compound secreted by OMVs (17, 54).”
• The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa (2012, neutral): “aeruginosa, within membrane vesicles (128, 129).”
• Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles (2010, background): “For example, Pseudomonas OM vesicles include virulence-associated enzymes, antimicrobial quinolines, and quorum-sensing molecules (70, 89, 91, 92, 113).”
• Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “Transportation of these signals is not well understood, but it is proposed as being mediated by free diffusion, membrane transporters such as specific efflux systems or membrane vesicles (Mashburn and Whiteley, 2005; Martinez et al., 2009; Alcalde-Rico et al., 2016).”
• Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules. (2009, background): “aeruginosa pqsH mutants that are unable to convert HHQ to PQS [33].”