Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

By T. Ellis, M. Kuehn. Microbiology and Molecular Biology Reviews, 2010

916 citations recorded by the source corpus.

Subfields: Epidemiology, Microbiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/8cf955abbbca6b194973f644adf693750d55513c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Lorraine O'Driscoll
2. M. Wood
3. M. Kuehn

In Microbiology

1. A. Manning
2. M. Tomás
3. G. Bou
4. A. Beceiro
5. M. Kuehn

In Public Health, Environmental and Occupational Health

1. A. Manning
2. M. Kuehn

Citations in the corpus

• Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options (2017, background): “They are composed of LPS, outer membrane and periplasmic proteins, phospholipids, and DNA or RNA, and are recognized as delivery vehicles for bacterial effectors to host cells (Ellis and Kuehn, 2010).”
• Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “Thus, there appears to be an inverse relationship between the increase in colistin resistance in A. baumannii mediated by changes in the LPS and the virulence of the species, or at least in the loss of resistance to other antibiotics, which can be considered a loss of fitness/virulence in an environ”
• Contribution of bacterial outer membrane vesicles to innate bacterial defense (2011, background): “OMVs are spherical portions of bacterial envelope containing outer membrane protein and lipid as well as soluble material contained in the lumen or bound to the external surface [2,3].”
• Biological properties of extracellular vesicles and their physiological functions (2015, background): “In this context, the study of EVs released by pathogens is a new and exciting field that may realistically contribute to a better understanding of the pathogenic process (602,603) (Fig.”
• Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation (2016, neutral): “OMVs are rich in LPS, and OMV-associated LPS is believed to be highly potent (Ellis and Kuehn, 2010).”
• Gut Bacteroides species in health and disease (2021, background): “These vesicles can be vehicles of pathogenicity as they can store and transport virulence factors over long distances.(27) In addition to spreaders of virulence factors, research indicates that these OMVs can be recognized as key modes of communication between bacterial spp.”
• UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies (2017, background): “UPEC toxins, adhesins, enzymes, and non-protein antigens like LPS are not released as soluble molecules; rather, they are associated with outer-membrane vesicles, which bud off the surface of Gram-negative bacteria during all stages of growth (Figure 2; Ellis and Kuehn, 2010).”
• Cells release subpopulations of exosomes with distinct molecular and biological properties (2016, methodology): “To understand the potential functional differences between the proteins identified in the distinct vesicle subpopulations, we performed GO enrichment analysis using 4 different protein lists: (1) the full list of all identified proteins across EV populations, and (2) MV, (3) LD-Exo and (4) HD-Exo pr”