A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms

By Marie Allesen-Holm, K. Barken, Liang Yang, Mikkel Klausen, J. Webb, S. Kjelleberg, Søren Molin, M. Givskov, T. Tolker-Nielsen. Molecular Microbiology, 2006

990 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/b0b2470898dc27eb2696681a12d80aa1aa97d774

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

In Molecular Medicine

Citations in the corpus

A Functional DNase I Coating to Prevent Adhesion of Bacteria and the Formation of Biofilm (2013, background): “[15–17] These bacterial membrane-derived vesicles have long been known to contain DNA,[18] but only recently their presence in bacterial biofilms has been shown [19].”
Extracellular DNA in soil and sediment: fate and ecological relevance (2009, background): “During biofilm formation by Pseudomonas aeruginosa, active eDNA extrusion involved acylated homoserine lactone signalling molecules and was inhibited by halogenated furanone (HF) (Givskov et al. 1996; Hentzer et al. 2002, 2003; Allesen-Holm et al. 2006).”
Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials. (2012, background): “aeruginosa, Streptococcus intermedius and Streptococcus mutans [72,77].”
The EPS Matrix: The “House of Biofilm Cells” (2007, background): “aeruginosa, the release of e-DNA is under the control of quorum-sensing systems as well as iron regulation (1, 25).”
Pseudomonas aeruginosa Biofilms (2020, background): “eDNA can also be localized on the surface and the stalk of the mushroom-like microcolonies [46,47].”
The biofilm matrix (2010, background): “aeruginosa biofilms eDNA forms a grid-like structur”
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “…interaction of highly anionic DNAwith cations such asMg2+, Ca2+, Mn2+, and Zn2+, as a nutrient source during starvation, facilitating twitching motility and coordinating cell movements and conferring antibiotic resistance (Allesen-Holm et al., 2006; Mulcahy et al., 2008; Gloag et al., 2013).”
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, background): “showed that eDNA is organized in distinct patterns and localizes in the stalk portion of the mushroom-shaped biofilms (Allesen-Holm et al. 2006).”
Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix (2009, background): “Our results (Figure 6) as well as other reports [10,20,37], indicate that death and lysis of cells occurs as a function of their spatial orientation within the biofilm, like that recently reported in S.”
The Social Lives of Microbes (2007, background): “…biofilms, which are responsible for the transport of nutrients and waste to and from cells deep in the biofilm or through which cells can disperse, and (b) releasing extracellular DNA that can be used for structuring biofilms (Allesen-Holm et al. 2006, Webb et al. 2003, Whitchurch et al. 2002).”
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “The source of the eDNA, whose composition is similar to that of genomic DNA, is speculated to be a result of whole-cell lysis or secretion of outer membrane vesicles containing DNA into the biofilm matrix (5).”
Evolving concepts in biofilm infections (2009, background): “aeruginosa biofilm development and both DNA and actin polymers facilitated binding and matrix cohesion likely mediated by type IV pili binding to DNA (Walker et al., 2005; Allesen-Holm et al., 2006).”
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses (2010, background): “aeruginosa biofilms (Allesen-Holm et al., 2006), which suggests that PQS may induce central hollowing.”